Division of General Radiology, Department of Radiology, Medical University of Graz, Auenbruggerplatz 9/P, 8036, Graz, Austria.
Division of Neuroradiology, Vascular and Interventional Radiology, Department of Radiology, Medical University of Graz, Graz, Austria.
Eur Radiol. 2024 Feb;34(2):981-993. doi: 10.1007/s00330-023-10017-3. Epub 2023 Aug 15.
To assess the feasibility, precision, and accuracy of left ventricular (LV) and left atrial (LA) volumetric function evaluation from native magnetic resonance (MR) multislice 4D flow magnitude images.
MATERIALS & METHODS: In this prospective study, 60 subjects without signs or symptoms of heart failure underwent 3T native cardiac MR multislice 4D flow and bSSFP-cine realtime imaging. LV and LA volumetric function parameters were evaluated from 4D flow magnitude (4D flow-cine) and bSSFP-cine data using standard software to obtain end-diastolic volume (EDV), end-systolic volume (ESV), ejection-fraction (EF), stroke-volume (SV), LV muscle mass (LVM), LA maximum volume, LA minimum volume, and LA total ejection fraction (LATEF). Stroke volumes derived from both imaging methods were further compared to 4D pulmonary artery flow-derived net forward volumes (NFV). Methods were compared by correlation and Bland-Altman analysis.
Volumetric function parameters from 4D flow-cine and bSSFP-cine showed high to very high correlations (r = 0.83-0.98). SV, LA volumes and LATEF did not differ between methods. LV end-diastolic and end-systolic volumes were slightly underestimated (EDV: -2.9 ± 5.8 mL; ESV: -2.3 ± 3.8 mL), EF was slightly overestimated (EF: 0.9 ± 2.6%), and LV mass was considerably overestimated (LVM: 39.0 ± 11.4 g) by 4D flow-cine imaging. SVs from both methods correlated very highly with NFV (r = 0.91 in both cases) and did not differ from NFV.
Native multislice 4D flow magnitude data allows precise evaluation of LV and LA volumetric parameters; however, apart from SV, LV volumetric parameters demonstrate bias and need to be referred to their respective normal values.
Volumetric function assessment from native multislice 4D flow magnitude images can be performed with routinely used clinical software, facilitating the application of 4D flow as a one-stop-shop functional cardiac MR exam, providing consistent, simultaneously acquired, volume and flow data.
• Native multislice 4D flow imaging allows evaluation of volumetric left ventricular and atrial function parameters. • Left ventricular and left atrial function parameters derived from native multislice 4D flow data correlate highly with corresponding standard cine-derived parameters. • Multislice 4D flow-derived volumetric stroke volume and net forward volume do not differ.
评估来自心脏 native MR 多层 4D 流量和 bSSFP 电影实时成像的左心室（LV）和左心房（LA）容积功能评估的可行性、精度和准确性。
在这项前瞻性研究中，60 名无心力衰竭症状或体征的患者接受了 3T native 心脏 MR 多层 4D 流量和 bSSFP 电影实时成像。使用标准软件从 4D 流量（4D flow-cine）和 bSSFP 电影数据中评估 LV 和 LA 容积功能参数，以获得舒张末期容积（EDV）、收缩末期容积（ESV）、射血分数（EF）、每搏量（SV）、左心室心肌质量（LVM）、LA 最大容积、LA 最小容积和 LA 总射血分数（LATEF）。进一步将两种成像方法获得的 SV 与 4D 肺动脉流量衍生的净前向体积（NFV）进行比较。通过相关性和 Bland-Altman 分析比较方法。
来自 4D flow-cine 和 bSSFP 电影的容积功能参数具有高至非常高的相关性（r = 0.83-0.98）。SV、LA 容积和 LATEF 两种方法之间无差异。LV 舒张末期和收缩末期容积略低估（EDV：-2.9 ± 5.8 mL；ESV：-2.3 ± 3.8 mL），EF 略高估（EF：0.9 ± 2.6%），LV 质量高估明显（LVM：39.0 ± 11.4 g）。两种方法的 SV 与 NFV 高度相关（两种情况下 r = 0.91），与 NFV 无差异。
心脏 native 多层 4D 流量数据可精确评估 LV 和 LA 容积参数；但是，除 SV 外，LV 容积参数显示出偏差，需要参考其各自的正常值。
从心脏 native 多层 4D 流量数据可以进行容积左心室和心房功能参数的评估；然而，除 SV 外，LV 容积参数存在偏差，需要参考各自的正常值。
• 心脏 native 多层 4D 流量成像可评估左心室和左心房容积功能参数。• 来自 native 多层 4D 流量数据的左心室和左心房功能参数与相应的标准电影衍生参数高度相关。• 多层 4D 流量衍生的容积每搏量和净前向量没有差异。
