Furlan A J, Whisnant J P, Elveback L R
Ann Neurol. 1979 Apr;5(4):367-73. doi: 10.1002/ana.410050410.
This population study describes the experience with primary intracerebral hemorrhage (PIH) in residents of Rochester, MN, for the 32-year period from 1945 through 1976. The average annual age-adjusted incidence rate for PIH was 12.1 per 100,000 population, and the incidence for all cases of spontaneous intracerebral hemorrhage was 15.2 per 100,000. The PIH rates were higher for males than for females, and they increased steadily with age. When patients on long-term anticoagulant therapy were excluded, there was a steady decrease in the average annual age-adjusted incidence rate for PIH in each succeeding 8-year interval since 1945. Prehemorrhage hypertension, present overall in 89% of patients, was much more frequent and severe in the earlier years of the study. The frequency and severity of prehemorrhage hypertension also varied inversely with age in the population with PIH. The median age at the onset of PIH increased from 65 years for the period 1945 through 1952 to 71 years for 1969 through 1976.
这项人群研究描述了1945年至1976年这32年间明尼苏达州罗切斯特市居民原发性脑出血（PIH）的情况。PIH的年龄调整后年平均发病率为每10万人12.1例，所有自发性脑出血病例的发病率为每10万人15.2例。男性的PIH发病率高于女性，且随年龄稳步上升。排除长期接受抗凝治疗的患者后，自1945年以来，每8年间隔期内PIH的年龄调整后年平均发病率持续下降。出血前高血压在所有患者中总体占89%，在研究早期更为常见和严重。在PIH人群中，出血前高血压的频率和严重程度也与年龄呈反比。PIH发病的中位年龄从1945年至1952年期间的65岁增加到1969年至1976年期间的71岁。
