丙酸倍氯米松气雾剂鼻内给药在花粉症中的局部作用
Local effect of intranasal beclomethasone dipropionate aerosol in hay fever.
作者信息
Mygind N
出版信息
Br Med J. 1973 Nov 24;4(5890):464-6. doi: 10.1136/bmj.4.5890.464.
Abstract
The effect of a daily dose of 400 mug beclomethasone dipropionate aerosol intranasally has been investigated in a double-blind cross-over trial in 29 patients with hay fever. The effect on the nasal symptoms was so pronounced in 25 patients that further symptomatic treatment was unnecessary. Beclomethasone dipropionate aerosol had, on the other hand, no direct effect on itching in the eyes, which is in accordance with the fact that biochemical investigations did not show any sign of suppression of the adrenal function. It is concluded that beclomethasone dipropionate aerosol intranasally is an effective and apparently harmless way of controlling the nasal symptoms in hay fever.
摘要
在一项针对29名花粉热患者的双盲交叉试验中，研究了每日经鼻给予400微克二丙酸倍氯米松气雾剂的效果。25名患者的鼻部症状改善显著，无需进一步对症治疗。另一方面，二丙酸倍氯米松气雾剂对眼部瘙痒无直接作用，这与生化检查未显示肾上腺功能受抑制的结果相符。结论是，经鼻使用二丙酸倍氯米松气雾剂是控制花粉热鼻部症状的一种有效且明显无害的方法。
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