Liubimov L K, Fateeva L I, Sergeeva L A
Antibiotiki. 1979 Apr;24(4):281-4.
The efficacy of amphotericin B powder of the Soviet production was studied as a therapeutic agent in experimental zoonotic leishmaniosis of the skin form of mice and hamsters. Amphotericin B was administered per os and its action was compared with that of monomycin injected subcutaneously (50 mg/kg). Amphotericin B in a dose of 150 mg/kg administered for 30 days protected 96+/-0.07 and 76.4+/-0.9 per cent of the mice and hamsters respectively from development of the leishmaniosis clinical signs, 68.8+/-0.04 per cent of the animals being cured (in the treatment experiments). The effect of the antibiotic was analogous to that of monomycin administered parenterally. The study of the kinetics of amphotericin B showed that the antibiotic was well absorbed from the digestive tract of the animals into the blood which provided the chemotherapeutic effect.
对苏联生产的两性霉素B粉剂作为治疗小鼠和仓鼠皮肤型实验性人畜共患利什曼病的治疗剂进行了研究。两性霉素B经口给药，并将其作用与皮下注射的莫能霉素（50毫克/千克）的作用进行比较。以150毫克/千克的剂量给予两性霉素B 30天，分别使96±0.07%的小鼠和76.4±0.9%的仓鼠免受利什曼病临床症状的发展，68.8±0.04%的动物被治愈（在治疗实验中）。该抗生素的效果与非肠道给予的莫能霉素的效果相似。对两性霉素B动力学的研究表明，该抗生素能很好地从动物消化道吸收进入血液，从而产生化疗效果。
