Monte Thais Miguel, Lima Júnior Edmar Maciel, de Moraes Filho Manoel Odorico, Koscky Paier Carlos Roberto, Rocha Rodrigues Felipe Augusto, Nunes Alves Ana Paula Negreiros, Mathor Mônica Beatriz, Raposo-Amaral Cassio Eduardo
Institute of Plastic and Craniofacial Surgery, SOBRAPAR Hospital, Campinas, São Paulo, Brazil.
J Craniofac Surg. 2023 Oct 1;34(7):2030-2033. doi: 10.1097/SCS.0000000000009600. Epub 2023 Aug 15.
Tilapia skin has already been used in various medical scenarios, but there are no studies showing the use of tilapia skin for hand reconstruction in Apert syndrome. The objective of this study is to determine whether the use of tilapia skin during graft bed preparation for children with Apert syndrome can shorten wound reepithelialization intervals, reduce the number of dressing changes, and decrease patient discomfort.
This is a prospective study on consecutive patients with Apert syndrome who underwent hand reconstruction at our Hospital. Patients were divided into 2 groups: (1) a control group consisting of patients who underwent conventional digit separation hand reconstruction surgery (2) an experimental group consisting of patients who underwent similar digit separation hand reconstruction surgery that commenced with the placement of a thin layer of tilapia skin at the raw commissures during a first operation, which was subsequently replaced by an autologous skin graft during a second operation staged 10 days postoperatively. Pain assessment was performed using the Visual Analog Scale. The number of dressing changes was also assessed. A T test compared the total number of dressings changes and pain data.
Experimental group patients (n = 8) required an average of 9.4 days of daily dressing changes, and control group patients (n = 5) required an average of 20.8 days of daily dressing changes ( P < 0.05) and tended to experience significantly less pain when compared with patients in the control group ( P = 0.079).
Tilapia skin can shorten wound reepithelialization intervals by reducing the total number of dressing changes.
罗非鱼皮已被应用于多种医疗场景，但尚无关于罗非鱼皮用于Apert综合征手部重建的研究。本研究的目的是确定在为Apert综合征患儿准备植皮床时使用罗非鱼皮是否能缩短伤口再上皮化时间、减少换药次数并减轻患者不适。
这是一项对在我院接受手部重建的连续性Apert综合征患者进行的前瞻性研究。患者分为两组：（1）对照组，由接受传统手指分离手部重建手术的患者组成；（2）实验组，由接受类似手指分离手部重建手术的患者组成，在首次手术时于创面交界处放置一层薄薄的罗非鱼皮，术后10天进行二期手术时用自体皮移植替换。使用视觉模拟量表进行疼痛评估，同时评估换药次数。采用t检验比较换药总数和疼痛数据。
实验组患者（n = 8）平均每日换药9.4天，对照组患者（n = 5）平均每日换药20.8天（P < 0.05），且与对照组患者相比疼痛明显减轻（P = 0.079）。
罗非鱼皮可通过减少换药总数来缩短伤口再上皮化时间。
