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大麻对人类健康的不良影响。

Adverse Impact of Cannabis on Human Health.

机构信息

Stanford Cardiovascular Institute, Stanford University School of Medicine, Stanford, California, USA; email:

Department of Medicine, Division of Cardiovascular Medicine, Stanford University School of Medicine, Stanford, California, USA.

出版信息

Annu Rev Med. 2024 Jan 29;75:353-367. doi: 10.1146/annurev-med-052422-020627. Epub 2023 Aug 15.

Abstract

Cannabis, the most commonly used recreational drug, is illicit in many areas of the world. With increasing decriminalization and legalization, cannabis use is increasing in the United States and other countries. The adverse effects of cannabis are unclear because its status as a Schedule 1 drug in the United States restricts research. Despite a paucity of data, cannabis is commonly perceived as a benign or even beneficial drug. However, recent studies show that cannabis has adverse cardiovascular and pulmonary effects and is linked with malignancy. Moreover, case reports have shown an association between cannabis use and neuropsychiatric disorders. With growing availability, cannabis misuse by minors has led to increasing incidences of overdose and toxicity. Though difficult to detect, cannabis intoxication may be linked to impaired driving and motor vehicle accidents. Overall, cannabis use is on the rise, and adverse effects are becoming apparent in clinical data sets.

摘要

大麻是世界上最常用的消遣性药物,在许多地区属于非法药物。随着大麻的使用在越来越多的国家和地区被合法化和非刑事化,美国和其他国家的大麻使用量也在增加。由于大麻在美国被列为附表 I 药物,限制了对其的研究,因此其不良影响仍不明确。尽管数据匮乏,但大麻通常被认为是一种良性甚至有益的药物。然而,最近的研究表明,大麻会对心血管和肺部产生不良影响,并与恶性肿瘤有关。此外,病例报告显示,大麻的使用与神经精神疾病之间存在关联。随着大麻供应的增加,未成年人滥用大麻导致中毒和毒性的发生率不断上升。尽管难以检测到,但大麻中毒可能与驾驶能力受损和机动车事故有关。总的来说,大麻的使用呈上升趋势,其不良影响在临床数据集中也逐渐显现。

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