Koren Gideon, Cohen Rana
Adelson Faculty of Medicine, Ariel University, 40700, Ariel, Israel.
Motherisk Israel Program, Shamir Hospital, Be'er Ya'akov, Israel.
J Cannabis Res. 2020 Jan 30;2(1):4. doi: 10.1186/s42238-020-0017-6.
Hyperemesis Gravidarum (HG) responds only partially to standard antiemetic medications. Cannabis has been known to possess antiemetic effects and there are several medicinal cannabinoids used as anti -emetics for cancer chemotherapy. Its favorable use for HG has been described in social media, but not in the medical literature.
We evaluated 4 women with HG counseled by the Motherisk Program, before and following the use of cannabis. Using the validated Pregnancy Unique Quantification of Emesis (PUQE) scoring system and employing the Student's paired t test, we compared changes in symptoms following initiation of cannabis.
There was a highly significant improvement in symptoms: PUQE score improved from 14.5+/- 1 to 7.5+/- 0.58(p = 0.0004). Cannabis use was associated with a significant increase in the PUQE Quality of Life scale, from 2+/- 0.82 to 7+/- 0.82 (p = 0.0012).
The results suggest that cannabis may be effective for HG, and should be studied in appropriately powered, controlled studies, fully considering potential fetal risks.
妊娠剧吐（HG）对标准止吐药物仅部分有效。已知大麻具有止吐作用，并且有几种药用大麻素被用作癌症化疗的止吐药。其在妊娠剧吐中的良好应用已在社交媒体中有所描述，但医学文献中尚无相关记载。
我们评估了4名接受Motherisk计划咨询的妊娠剧吐女性，在使用大麻之前和之后的情况。使用经过验证的妊娠呕吐独特量化（PUQE）评分系统，并采用学生配对t检验，我们比较了开始使用大麻后症状的变化。
症状有非常显著的改善：PUQE评分从14.5±1提高到7.5±0.58（p = 0.0004）。使用大麻与PUQE生活质量量表显著提高相关，从2±0.82提高到7±0.82（p = 0.0012）。
结果表明大麻可能对妊娠剧吐有效，应在充分考虑潜在胎儿风险的情况下，在适当规模的对照研究中进行研究。
