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Selective lesions of mesostriatal dopamine neurons ameliorate hypoglycemic damage in the caudate-putamen.

作者信息

Lindvall O, Auer R N, Siesjö B K

出版信息

Exp Brain Res. 1986;63(2):382-6. doi: 10.1007/BF00236856.

DOI:10.1007/BF00236856
PMID:3758254
Abstract

Unilateral 6-hydroxydopamine lesion of the mesostriatal dopaminergic system was found to ameliorate neuronal necrosis in the caudate-putamen following 30 min of insulin-induced hypoglycemic coma. We propose that increased release of dopamine in the striatum during hypoglycemia or in the recovery period potentiates a deleterious neuronal hyperexcitation, probably induced by excessive release of glutamate or related compounds, thereby aggravating neuronal necrosis.

摘要

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本文引用的文献

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