Department of Internal Medicine, Division of Medical Oncology, Center for Tobacco Research, The Ohio State University Wexner Medical Center, Columbus, Ohio, USA.
Department of Population and Public Health Sciences, University of Southern California Keck School of Medicine, Los Angeles, California, USA.
Thorax. 2024 Jan 18;79(2):163-168. doi: 10.1136/thorax-2022-218670.
Electronic cigarette (e-cigarette) aerosol contains volatile aldehydes, including flavourings and oxidant metals with known pulmonary toxicity.
To evaluate the associations of e-cigarette use with symptoms of wheeze, bronchitic symptoms and shortness of breath (SOB) across 4 years of prospective data.
Participants completed questionnaires on respiratory symptoms and past 30-day e-cigarette, cigarette and cannabis use in 2014 (wave 1; N=2094; mean age 17.3 years, SD=0.6 years). Follow-up information was collected in 2015 (wave 2; n=1609), 2017 (wave 3; n=1502) and 2018 (wave 4; n=1637) using online surveys. Mixed-effects logistic regression models evaluated associations of e-cigarette use with respiratory symptoms.
Participants were mostly Hispanic white (51.8%) and evenly representative by sex (49.6% female; 50.4% male). Compared with never e-cigarette users, past 30-day e-cigarette users reported increased odds of wheeze (OR 1.81; 95% CI 1.28, 2.56), bronchitic symptoms (OR 2.06; 95% CI 1.58, 2.69) and SOB (OR 1.78; 95% CI 1.23, 2.57), adjusting for study wave, age, sex, race, lifetime asthma diagnosis and parental education. Effect estimates were attenuated (wheeze (OR 1.41; 95% CI 0.99, 2.01), bronchitic symptoms (OR 1.55; 95% CI 1.18, 2.05), SOB (OR 1.48; 95% CI 1.01, 2.18)), after adjusting additionally for current cigarette use, cannabis use and secondhand exposure to e-cigarettes/cigarettes/cannabis.
E-cigarette use in young adults was associated with respiratory symptoms, independent of combustible cannabis and cigarette exposures.
电子烟（e-cigarette）气溶胶含有挥发性醛类物质，包括有已知肺部毒性的调味剂和氧化剂金属。
通过 4 年的前瞻性数据评估电子烟使用与喘息、支气管炎症状和呼吸急促（SOB）症状之间的关联。
参与者在 2014 年（第 1 波；N=2094；平均年龄 17.3 岁，SD=0.6 岁）完成了关于呼吸道症状和过去 30 天电子烟、香烟和大麻使用情况的调查问卷。在 2015 年（第 2 波；n=1609）、2017 年（第 3 波；n=1502）和 2018 年（第 4 波；n=1637）通过在线调查收集了随访信息。混合效应逻辑回归模型评估了电子烟使用与呼吸道症状之间的关联。
参与者主要为西班牙裔白人（51.8%），性别分布均匀（49.6%为女性；50.4%为男性）。与从不使用电子烟的人相比，过去 30 天使用电子烟的人报告喘息（OR 1.81；95%CI 1.28，2.56）、支气管炎症状（OR 2.06；95%CI 1.58，2.69）和呼吸急促（OR 1.78；95%CI 1.23，2.57）的几率更高，调整了研究波次、年龄、性别、种族、终身哮喘诊断和父母教育程度。在进一步调整当前香烟使用、大麻使用以及二手电子烟/香烟/大麻暴露情况后，效应估计值减弱（喘息（OR 1.41；95%CI 0.99，2.01）、支气管炎症状（OR 1.55；95%CI 1.18，2.05）、呼吸急促（OR 1.48；95%CI 1.01，2.18））。
在年轻成年人中，电子烟使用与呼吸道症状有关，与可燃大麻和香烟暴露无关。
