Department of Obstetrics and Gynecology, Shandong Provincial Hospital, Shandong University, Jinan, Shandong, China.
Medical Integration and Practice Center, Cheeloo College of Medicine, Shandong University, Jinan, Shandong, China.
Expert Opin Ther Targets. 2023 Jul-Dec;27(8):745-756. doi: 10.1080/14728222.2023.2248376. Epub 2023 Aug 24.
The largest transmembrane mucin, mucin 16 (MUC16), contains abundant glycosylation sites on the molecular surface, allowing it to participate in various molecular pathways. When cells lose polarity and become cancerous, MUC16 is overexpressed, and more of the extracellular region (cancer antigen [CA]125) is released into serum and possibly, promote the development of diseases. Thus, MUC16 plays an indispensable role in clinical research and application.
This review summarizes the update proposed role of MUC16 in carcinogenesis and metastasis. Most importantly, we prospect its potential value in targeted therapy after screening 1226 articles published within the last 10 years from PubMed. Two reviewers screened each record and each report retrieved independently. We have summarized the progress of MUC16/CA125 in basic research and clinical application, and predicted its possible future development directions.
As an important noninvasive co-factor in the diagnosis of gynecological diseases, MUC16 has been used for a long time, especially in the diagnosis and treatment of ovarian cancer. The overexpression of MUC16 plays a very obvious role in regulating inflammatory response, supporting immune suppression, and promoting the proliferation, division, and metastasis of cancer cells. In the next 20 years, there will be a luxuriant clinical application of MUC16 as a target for immune monitoring and immunotherapy.
最大的跨膜黏蛋白 MUC16 分子表面含有丰富的糖基化位点，使其能够参与多种分子途径。当细胞失去极性并癌变时，MUC16 过度表达，更多的细胞外区域（癌抗原 [CA]125）被释放到血清中，并可能促进疾病的发展。因此，MUC16 在临床研究和应用中起着不可或缺的作用。
本文综述了 MUC16 在致癌和转移中作用的最新研究进展。最重要的是，我们在过去 10 年中从 PubMed 筛选了 1226 篇文章，对 MUC16 进行了靶向治疗的潜在价值进行了预测。两位审稿人分别筛选了每一条记录和检索到的每一篇报告。我们总结了 MUC16/CA125 在基础研究和临床应用中的进展，并预测了其未来可能的发展方向。
作为妇科疾病诊断中重要的非侵入性辅助因子，MUC16 已经被长期使用，尤其是在卵巢癌的诊断和治疗中。MUC16 的过度表达在调节炎症反应、支持免疫抑制以及促进癌细胞的增殖、分裂和转移方面发挥着非常明显的作用。在未来 20 年，MUC16 将作为免疫监测和免疫治疗的靶点得到广泛的临床应用。
