Dienst Cardiologie, Centrum Hart- en Vaatziekten, Universitair Ziekenhuis Brussel, Laarbeeklaan 101, 1090, Brussels, Belgium.
Curr Cardiol Rep. 2023 Oct;25(10):1113-1121. doi: 10.1007/s11886-023-01933-3. Epub 2023 Aug 16.
We aim to give a concise overview of the different clinical manifestations of both acute and long-term radiotherapy-related pericardial diseases, the underlying pathophysiology as well as the diagnosis and treatment options.
Radiotherapy-related pericardial disease is common, but despite radiotherapy being a cornerstone of many cancer treatments, this disease entity is relatively underrepresented in clinical trials, resulting in a paucity of research data on pathophysiology and management. Since the development of innovative cancer treatments, survival has significantly improved. Therefore, the importance of long-term treatment-related side effects increases, most notably cancer treatment-related cardiovascular toxicity. In patients undergoing radiotherapy as a part of their cancer treatment, radiotherapy-related pericardial disease can manifest early (during or shortly after radiotherapy administration) or very late (several years to decades after treatment). This exceptionally long latency period confronts physicians with treatment-related side effects of radiotherapy regimens that may have been abandoned already.
本文旨在简要概述急性和长期放射性治疗相关心包疾病的不同临床表现、潜在病理生理学以及诊断和治疗选择。
放射性治疗相关心包疾病较为常见，但尽管放射治疗是许多癌症治疗的基石，这种疾病在临床试验中相对代表性不足，导致在病理生理学和管理方面的研究数据有限。随着创新癌症治疗方法的发展，患者的生存率显著提高。因此，长期治疗相关副作用的重要性增加，尤其是癌症治疗相关的心血管毒性。在接受放射治疗作为癌症治疗一部分的患者中，放射性治疗相关心包疾病可早发（在放射治疗期间或治疗后不久）或很晚发（治疗后数年至数十年）。这种异常长的潜伏期使医生面临可能已经被放弃的放射治疗方案的治疗相关副作用。
