Bone and Joint Reconstruction Research Center, Department of Orthopedics, School of Medicine, Iran University of Medical Sciences, Tehran 1449614535, Iran.
Gastroenterology and Liver Diseases Research Center, Research Institute for Gastroenterology and Liver Diseases, Shahid Beheshti University of Medical Sciences, Tehran 1983969411, Iran.
ACS Biomater Sci Eng. 2023 Sep 11;9(9):5186-5204. doi: 10.1021/acsbiomaterials.3c00178. Epub 2023 Aug 16.
This systematic review and meta-analysis focused on the effectiveness of biomaterials integrated with specific microRNAs (miRNAs) for bone fracture repair treatment. We conducted a comprehensive search of the PubMed, Web of Science, and Scopus databases, identifying 42 relevant papers up to March 2022. Hydrogel-based scaffolds were the most commonly used, incorporating miRNAs like miR-26a, miR-21, and miR-222, with miR-26a being the most prevalent. The meta-analysis revealed significant benefits of incorporating miRNAs into scaffolds for bone repair, particularly in hydrogel scaffolds. However, some controversies were observed among studies, presenting challenges in selecting appropriate miRNAs for this purpose. The study concludes that incorporating specific miRNAs into bone biomaterials enhances bone regeneration, but further trials comparing different biomaterials and miRNAs are necessary to validate their potential applications for bone tissue regeneration.
本系统评价和荟萃分析专注于将特定 microRNAs（miRNAs）与生物材料结合用于骨骨折修复治疗的效果。我们全面检索了 PubMed、Web of Science 和 Scopus 数据库，截至 2022 年 3 月，共确定了 42 篇相关文献。水凝胶基支架是最常用的支架，其中包含 miR-26a、miR-21 和 miR-222 等 miRNAs，miR-26a 是最常见的。荟萃分析显示，将 miRNAs 掺入支架中进行骨修复具有显著益处，特别是在水凝胶支架中。然而，研究中存在一些争议，这给为此目的选择合适的 miRNAs 带来了挑战。该研究得出结论，将特定的 miRNAs 掺入骨生物材料中可增强骨再生，但需要进一步的试验比较不同的生物材料和 miRNAs，以验证它们在骨组织再生方面的潜在应用。
