Department of Bio & Nanotechnology, Guru Jambheshwar University of Science and Technology, Hisar 125001, Haryana, India.
Department of Biotechnology, Guru Nanak Dev University, Amritsar 143005, Punjab, India.
Int J Biol Macromol. 2022 May 31;208:243-259. doi: 10.1016/j.ijbiomac.2022.03.030. Epub 2022 Mar 10.
Our body is built to heal from inside out naturally but wide-ranging medical conditions necessitate the need for artificial assistance, and therefore, something that can assist the body to heal wounds and damaged tissues quickly and efficiently is of utmost importance. Tissue engineering technology helps to regenerate new tissue to replace the diseased or injured one. The technology uses biodegradable porous three-dimensional scaffolds for mimicking the structure and functions of the natural extracellular matrix. The material and design of scaffolds are critical areas of biomaterial research. Biomaterial-based three-dimensional structures have been the most promising material to serve as scaffolds for seeding cells, both in vivo and in vitro. One such material is polyhydroxyalkanoates (PHAs) which are thermoplastic biopolyesters that are highly suitable for this purpose due to their enhanced biocompatibility, biodegradability, thermo-processability, diverse mechanical properties, non-toxicity and natural origin. Moreover, they have tremendous possibilities of customization through biological physical and chemical modification as well as blending with other materials. They are being used for several tissue engineering applications such as bone graft substitute, cardiovascular patches, stents, for nerve repair and in implantology as valves and sutures. The present review overviews usage of a multitude of PHA-based biomaterials for a wide range of tissue engineering applications, based on their properties suitable for the specific applications.
我们的身体天生就具有从内部自然治愈的能力，但广泛的医疗条件需要人工辅助，因此，能够帮助身体快速有效地治愈伤口和受损组织的东西是至关重要的。组织工程技术有助于再生新的组织来替代患病或受损的组织。该技术使用可生物降解的多孔三维支架来模拟天然细胞外基质的结构和功能。支架的材料和设计是生物材料研究的关键领域。基于生物材料的三维结构一直是作为细胞接种支架的最有前途的材料，无论是在体内还是体外。聚羟基烷酸酯（PHA）就是这样一种材料，它是热塑性生物聚酯，由于其增强的生物相容性、生物降解性、热加工性、多样的机械性能、无毒性和天然来源，非常适合这种用途。此外，通过生物物理和化学改性以及与其他材料混合，它们具有极大的定制可能性。它们被用于多种组织工程应用，如骨移植替代物、心血管贴片、支架、神经修复以及植入物如瓣膜和缝线。本综述根据 PHA 基生物材料适合特定应用的特性，概述了它们在广泛的组织工程应用中的多种用途。
