Department of Biotechnology, Yonsei University, Seoul 03722, Republic of Korea.
Department of Physiology, Yonsei University College of Medicine, Seoul 03722, Republic of Korea.
Biofabrication. 2023 Aug 17;15(4). doi: 10.1088/1758-5090/aceaae.
Thesimulation of organs resolves the accuracy, ethical, and cost challenges accompanyingexperiments. Organoids and organs-on-chips have been developed to model the, real-time biological and physiological features of organs. Numerous studies have deployed these systems to assess the, real-time responses of an organ to external stimuli. Particularly, organs-on-chips can be most efficiently employed in pharmaceutical drug development to predict the responses of organs before approving such drugs. Furthermore, multi-organ-on-a-chip systems facilitate the close representations of theenvironment. In this review, we discuss the biosensing technology that facilitates the, real-time measurements of organ responses as readouts on organ-on-a-chip systems, including multi-organ models. Notably, a human-on-a-chip system integrated with automated multi-sensing will be established by further advancing the development of chips, as well as their assessment techniques.
器官模拟解决了实验伴随的准确性、伦理和成本挑战。类器官和器官芯片已被开发出来，以模拟器官的实时生物学和生理学特征。许多研究都部署了这些系统来评估器官对外部刺激的实时反应。特别是，器官芯片可以在药物开发中最有效地用于预测在批准这些药物之前器官的反应。此外，多器官芯片系统有利于环境的紧密表示。在这篇综述中，我们讨论了促进器官反应的实时测量的生物传感技术，作为器官芯片系统（包括多器官模型）的读出信号。值得注意的是，通过进一步推进芯片及其评估技术的发展，将建立一个集成了自动化多传感的人芯片系统。
