Department of Biochemisty, Istanbul Faculty of Medicine, Istanbul University, Istanbul, Türkiye.
Department of Radiology, Istanbul Faculty of Medicine, Istanbul University, Istanbul, Türkiye.
Angiology. 2024 Sep;75(8):779-785. doi: 10.1177/00033197231183228. Epub 2023 Aug 17.
Endothelial dysfunction (ED) plays a prominent role in the pathogenesis of preeclampsia (PE). There is a need for non-invasive methods to assess endothelial function in preeclamptic patients. In the present study, adropin, autotaxin (ATX), and lysophosphatidic acid (LPA) were evaluated as indicators of ED. Patients diagnosed with PE and healthy pregnant women (n = 42 for each group) were compared. After measuring flow-mediated dilation (FMD), the participants were stratified as ED (+) or ED (-) based on a cut-off value of 6.5%. The PE patients were divided as early/late onset PE and severe/mild PE. Adropin, ATX, and LPA levels were measured, and their relevance to ED was evaluated. Student t, Mann-Whitney U, or ANOVA tests were used for statistics, as appropriate. Adropin levels were diminished in the ED (+) group, whereas ATX and LPA levels were increased. The decrease in adropin levels was more pronounced in severe PE, showing a positive correlation with the FMD. In the logistic regression model, adropin was the only parameter that was an independent variable for the FMD test (P < .001). Adropin measurements in serum may be of value for disease follow-up in patients with PE.
内皮功能障碍（ED）在子痫前期（PE）的发病机制中起重要作用。需要有非侵入性的方法来评估子痫前期患者的内皮功能。在本研究中，评估了 adiponectin、autotaxin（ATX）和溶血磷脂酸（LPA）作为 ED 的指标。将诊断为 PE 的患者和健康孕妇（每组 42 人）进行比较。在测量血流介导的扩张（FMD）后，根据 6.5%的截断值将参与者分为 ED（+）或 ED（-）。将 PE 患者分为早发/晚发 PE 和严重/轻度 PE。测量 adiponectin、ATX 和 LPA 水平，并评估其与 ED 的相关性。适当使用学生 t、Mann-Whitney U 或 ANOVA 检验进行统计分析。ED（+）组 adiponectin 水平降低，而 ATX 和 LPA 水平升高。严重 PE 患者的 adiponectin 水平下降更为明显，与 FMD 呈正相关。在逻辑回归模型中，adropin 是 FMD 测试的唯一独立变量（P<0.001）。血清中 adiponectin 的测量值可能对 PE 患者的疾病随访有价值。
