Sanz-Horta Raúl, Matesanz Ana, Gallardo Alberto, Reinecke Helmut, Jorcano José Luis, Acedo Pablo, Velasco Diego, Elvira Carlos
Department of Applied Macromolecular Chemistry, Institute of Polymer Science and Technology, Spanish National Research Council (ICTP-CSIC), Madrid, Spain.
Department of Bioengineering, Universidad Carlos III de Madrid (UC3M), Madrid, Spain.
J Tissue Eng. 2023 Aug 14;14:20417314231190288. doi: 10.1177/20417314231190288. eCollection 2023 Jan-Dec.
Fibrin is a promising natural polymer that is widely used for diverse applications, such as hemostatic glue, carrier for drug and cell delivery, and matrix for tissue engineering. Despite the significant advances in the use of fibrin for bioengineering and biomedical applications, some of its characteristics must be improved for suitability for general use. For example, fibrin hydrogels tend to shrink and degrade quickly after polymerization, particularly when they contain embedded cells. In addition, their poor mechanical properties and batch-to-batch variability affect their handling, long-term stability, standardization, and reliability. One of the most widely used approaches to improve their properties has been modification of the structure and composition of fibrin hydrogels. In this review, recent advances in composite fibrin scaffolds, chemically modified fibrin hydrogels, interpenetrated polymer network (IPN) hydrogels composed of fibrin and other synthetic or natural polymers are critically reviewed, focusing on their use for tissue engineering.
纤维蛋白是一种很有前景的天然聚合物，被广泛应用于多种领域，如止血胶、药物和细胞递送载体以及组织工程基质。尽管在将纤维蛋白用于生物工程和生物医学应用方面取得了重大进展，但为了适用于一般用途，仍需改进其一些特性。例如，纤维蛋白水凝胶在聚合后往往会迅速收缩和降解，尤其是当它们含有嵌入细胞时。此外，其较差的机械性能和批次间的差异会影响其操作、长期稳定性、标准化和可靠性。改善其性能最广泛使用的方法之一是对纤维蛋白水凝胶的结构和组成进行改性。在这篇综述中，对复合纤维蛋白支架、化学改性纤维蛋白水凝胶、由纤维蛋白和其他合成或天然聚合物组成的互穿聚合物网络（IPN）水凝胶的最新进展进行了批判性综述，重点关注它们在组织工程中的应用。
