Li Dongying, Du Haocheng, Guo Wenmin, Chen Meigui, Guo Xiaoping, Li Pin, Zhou Yanrong, Chen Peng, Li Mengqi, Xu Yong
Key Laboratory of Hunan Province for Efficient Power System and Intelligent Manufacturing, College of Mechanical and Energy Engineering, Shaoyang University Shaoyang 422000 China
RSC Adv. 2023 Aug 15;13(35):24519-24535. doi: 10.1039/d3ra04273a. eCollection 2023 Aug 11.
Although polycaprolactone (PCL) matrix composites have been extensively studied, the weak interface with nanofillers limits their further applications in bone tissue engineering. Herein, this study has designed a porous bone scaffold model using the triply periodic minimal surfaces (TPMS), and the optimal porosity was determined by comparing the mechanical properties. A sodium stearate-modified PCL/tourmaline (PCL/TM) composite scaffold with a strong interfacial effect was prepared by selective laser sintering technology. Wherein, sodium stearate acts as a bridge to improve the interaction between TM and PCL interface, while promoting its uniform dispersion. The results showed that the PCL/3% modified TM specimens exhibit the optimum mechanical properties, and their ultimate tensile and compressive strength increases by 21.8% and 32.1%, respectively, compared with pure PCL. The factors of mechanical enhancement of composite scaffolds can be elaborated from the construction of interface bridges. On the one hand, the carboxyl group at one end of sodium stearate will interact with the hydroxyl group on the surface of TM to enhance interfacial adsorption by forming ionic bonds and hydrogen bonds. On the other hand, the hydrophobic long chain at the other end of sodium stearate is universally compatible with hydrophobic PCL, thereby improving the dispersion of TM. These characteristics make the PCL/TM composite scaffold a valuable reference for its application in bone tissue engineering.
尽管聚己内酯（PCL）基复合材料已得到广泛研究，但与纳米填料之间的弱界面限制了它们在骨组织工程中的进一步应用。在此，本研究利用三重周期极小曲面（TPMS）设计了一种多孔骨支架模型，并通过比较力学性能确定了最佳孔隙率。采用选择性激光烧结技术制备了具有强界面效应的硬脂酸钠改性PCL/电气石（PCL/TM）复合支架。其中，硬脂酸钠作为桥梁，改善了TM与PCL界面之间的相互作用，同时促进了其均匀分散。结果表明，PCL/3%改性TM试样表现出最佳力学性能，与纯PCL相比，其极限拉伸强度和抗压强度分别提高了21.8%和32.1%。复合支架力学增强的因素可以从界面桥的构建方面进行阐述。一方面，硬脂酸钠一端的羧基会与TM表面的羟基相互作用，通过形成离子键和氢键增强界面吸附。另一方面，硬脂酸钠另一端的疏水长链与疏水PCL具有普遍相容性，从而改善了TM的分散性。这些特性使得PCL/TM复合支架在骨组织工程中的应用具有重要参考价值。
