在布基纳法索农村地区，36-59 个月大的儿童中，膳食中维生素 A 前体和维生素 A 原类胡萝卜素的摄入量与血清视黄醇和类胡萝卜素浓度无关：一项横断面研究。

Dietary intake of preformed vitamin A and provitamin A carotenoids are not associated with serum retinol and carotenoid concentrations among children 36-59 months of age in rural Burkina Faso: a cross-sectional study.

机构信息

Unité Nutrition et Maladies Métaboliques, Institut de Recherche en Sciences de la Santé/Direction Régionale de l'Ouest, Bobo Dioulasso, Burkina Faso.

Public Health Nutrition Unit, Department of Public Health and Primary Care, Faculty of Health Sciences, Ghent University, 9000, Ghent, Belgium.

出版信息

Eur J Nutr. 2023 Dec;62(8):3311-3327. doi: 10.1007/s00394-023-03194-w. Epub 2023 Aug 17.

DOI:10.1007/s00394-023-03194-w

PMID:37589896

Abstract

PURPOSE

This study aimed to assess the association between dietary intake of preformed vitamin A (VA) and pro-VA carotenoids and serum retinol and carotenoid concentrations among 36-59-month-old children in a rural area in Burkina Faso.

METHODS

Two community-based cross-sectional studies were conducted in a rural area of Burkina Faso and included 115 children aged 36-59 months. Dietary intake of preformed VA and pro-VA was assessed directly by 24-h dietary recall. Serum retinol and carotenoid (α- and β-carotene, and β-cryptoxanthin) concentrations were measured. The associations between serum retinol and carotenoid concentrations and their respective dietary intake were assessed by multiple linear regression.

RESULTS

Geometric mean [95% CI] adjusted serum retinol concentration in children was 0.86 [0.81; 0.92] µmol/L. The prevalence of low adjusted serum retinol concentration (< 0.7 µmol/L) was 26.8%. Geometric mean [95% CI] serum carotenoid concentrations were: α-carotene (0.03 [0.02; 0.03] µmol/L), β-carotene (0.14 [0.12; 0.16] µmol/L), and β-cryptoxanthin (0.17 [0.15; 0.21] µmol/L). Dietary intakes of α- and β-carotene and adjusted serum retinol and α-carotene concentrations were significantly higher during the rainy season. In multiple linear regressions, no associations were found between dietary intakes of preformed VA and pro-VA carotenoids and serum retinol and carotenoid concentrations in children aged 36-59 months in Burkina Faso. There was no effect of season on the associations between preformed VA and pro-VA carotenoids intake and serum retinol and carotenoid concentrations.

CONCLUSIONS

This study shows that dietary intakes of preformed VA and pro-VA carotenoids based on 24-h dietary recall method cannot be used as proxy of serum retinol and carotenoid concentrations in this population.

TRIAL REGISTRATION

The study was registered retrospectively (22 March 2018) as a clinical trial with the Pan African Clinical Trials Registry (Cochrane South Africa; PACTR201803002999356).

摘要

目的

本研究旨在评估布基纳法索农村地区 36-59 个月大儿童中摄入预先形成的维生素 A（VA）和前维生素 A 类胡萝卜素与血清视黄醇和类胡萝卜素浓度之间的关系。

方法

在布基纳法索的一个农村地区进行了两项基于社区的横断面研究，纳入了 115 名 36-59 个月大的儿童。通过 24 小时膳食回忆直接评估预先形成的 VA 和前维生素 A 类胡萝卜素的膳食摄入量。测量血清视黄醇和类胡萝卜素（α-和β-胡萝卜素以及β-隐黄质）浓度。使用多元线性回归评估血清视黄醇和类胡萝卜素浓度与其各自膳食摄入量之间的关系。

结果

调整后的儿童血清视黄醇浓度几何平均值[95%置信区间]为 0.86[0.81; 0.92]µmol/L。低调整血清视黄醇浓度（<0.7µmol/L）的患病率为 26.8%。血清类胡萝卜素浓度的几何平均值[95%置信区间]为：α-胡萝卜素（0.03[0.02; 0.03]µmol/L），β-胡萝卜素（0.14[0.12; 0.16]µmol/L）和β-隐黄质（0.17[0.15; 0.21]µmol/L）。在雨季，α-和β-胡萝卜素以及调整后的血清视黄醇和α-胡萝卜素浓度的膳食摄入量显著更高。多元线性回归显示，在布基纳法索 36-59 个月大的儿童中，预先形成的 VA 和前维生素 A 类胡萝卜素的膳食摄入量与血清视黄醇和类胡萝卜素浓度之间没有关联。季节对预先形成的 VA 和前维生素 A 类胡萝卜素摄入量与血清视黄醇和类胡萝卜素浓度之间的关联没有影响。