Department of Pediatrics, Yantaishan Hospital, Yantai, 264003, China.
Department of ICU, Affiliated Qingdao Central Hospital of Qingdao University, Qingdao Cancer Hospital, Qingdao, 266000, China.
World J Surg Oncol. 2023 Aug 18;21(1):251. doi: 10.1186/s12957-023-03131-5.
To analyze the diagnostic value of computed tomography (CT), magnetic resonance imaging (MRI) combined with serum lactate dehydrogenase (LDH), neuron-specific enolase (NSE), carcinoembryonic antigen (CEA), and N-myc (MYCN) in the diagnosis of pediatric neuroblastoma.
Fifty-two children diagnosed with neuroblastoma were selected as the neuroblastoma group. During the same period, 52 children who visited our hospital with abdominal distension, diarrhea, constipation, and vomiting but were finally excluded from neuroblastoma were selected as the control group. CT and MRI were performed on all children.
Fifty-two cases of neuroblastoma of the central nervous system were confirmed by pathological examination. The levels of LDH, NSE, CEA, and MYCN in the neuroblastoma group were clearly higher than those in the control group (P < 0.05). The results of CT and MRI combined with serum LDH, NSE, CEA, and MYCN were false positive in 10 cases and false negative in 6 cases, which were consistent with the pathological results. The sensitivity of CT and MRI combined with serum LDH, NSE, CEA, and MYCN in the diagnosis of neuroblastoma was notably higher than that of the three alone (P < 0.05).
The imaging findings of CT and MRI in children with central nervous system neuroblastoma were definitely characteristic. MRI had higher diagnostic value than CT. The diagnostic value of CT and MRI combined with serum LDH, NSE, CEA, and MYCN was improved to some extent.
分析计算机断层扫描（CT）、磁共振成像（MRI）联合血清乳酸脱氢酶（LDH）、神经元特异性烯醇化酶（NSE）、癌胚抗原（CEA）和 N- myc（MYCN）在儿童神经母细胞瘤诊断中的价值。
选择 52 例经病理检查确诊为神经母细胞瘤的患儿作为神经母细胞瘤组，同期选择因腹胀、腹泻、便秘、呕吐等就诊我院但最终排除神经母细胞瘤的 52 例患儿作为对照组，所有患儿均进行 CT 和 MRI 检查。
经病理检查证实中枢神经系统神经母细胞瘤 52 例，神经母细胞瘤组 LDH、NSE、CEA、MYCN 水平明显高于对照组（P<0.05）；CT、MRI 联合血清 LDH、NSE、CEA、MYCN 检查结果假阳性 10 例，假阴性 6 例，与病理结果一致；CT、MRI 联合血清 LDH、NSE、CEA、MYCN 诊断神经母细胞瘤的灵敏度明显高于单独 3 项检查（P<0.05）。
中枢神经系统神经母细胞瘤患儿 CT、MRI 影像学表现具有一定特征性，MRI 诊断价值高于 CT，CT、MRI 联合血清 LDH、NSE、CEA、MYCN 检查可在一定程度上提高诊断价值。
