胞壁酰二肽和海藻糖二霉菌酸酯对小鼠抵抗刚地弓形虫和卡氏棘阿米巴感染的影响。

Effects of muramyl dipeptide and trehalose dimycolate on resistance of mice to Toxoplasma gondii and Acanthamoeba culbertsoni infections.

作者信息

Masihi K N, Bhaduri C R, Werner H, Janitschke K, Lange W

出版信息

Int Arch Allergy Appl Immunol. 1986;81(2):112-7. doi: 10.1159/000234118.

Abstract

The effects of synthetic muramyl dipeptide (MDP) and natural trehalose dimycolate (TDM) against parasitic infections by intracellular Toxoplasma gondii and free-living Acanthamoeba culbertsoni were studied. Significant resistance against oral T. gondii infection was induced by intraperitoneal pretreatment with TDM but not with MDP. The protective effect of TDM against T. gondii was corroborated by a significant reduction in the number of cysts in brains of pretreated animals and elevated serum antibody levels. Partial protection against lethal intranasal A. culbertsoni infection was conferred by specific immunization with viable trophozoites of nonpathogenic Acanthamoeba lugdunensis. The nonspecific resistance induced by intravenous pretreatment with MDP was similar to, whereas that stimulated by TDM was lesser than the protection conferred by A. lugdunensis. The Fc receptor-mediated phagocytosis of 51Cr-labeled sheep red blood cells by alveolar macrophages was enhanced by MDP. The phagocytic activity of peritoneal macrophages was increased by lower doses of TDM.

摘要

研究了合成的胞壁酰二肽（MDP）和天然海藻糖二霉菌酸酯（TDM）对细胞内寄生虫刚地弓形虫和自由生活的库氏棘阿米巴感染的影响。经腹腔预处理TDM可诱导对经口感染刚地弓形虫的显著抗性，而MDP则不能。预处理动物脑中囊肿数量显著减少以及血清抗体水平升高，证实了TDM对刚地弓形虫的保护作用。用无毒的鲁氏棘阿米巴活滋养体进行特异性免疫可对致死性鼻内感染库氏棘阿米巴提供部分保护。静脉预处理MDP诱导的非特异性抗性与鲁氏棘阿米巴提供的保护相似，而TDM刺激的非特异性抗性则小于鲁氏棘阿米巴提供的保护。MDP增强了肺泡巨噬细胞对51Cr标记绵羊红细胞的Fc受体介导的吞噬作用。较低剂量的TDM可增加腹腔巨噬细胞的吞噬活性。