胞壁酰二肽处理对小鼠抗弓形虫感染能力的影响。
Effects of muramyl dipeptide treatment on resistance to infection with Toxoplasma gondii in mice.
作者信息
Krahenbuhl J L, Sharma S D, Ferraresi R W, Remington J S
出版信息
Infect Immun. 1981 Feb;31(2):716-22. doi: 10.1128/iai.31.2.716-722.1981.
Abstract
Studies were carried out to determine whether treatment of mice with the synthetic adjuvant muramyl dipeptide afforded any resistance to infection with the obligate intracellular protozoan Toxoplasma gondii. Marked resistance to lethal challenge infection was observed in CBA but not C57BL/6 mice pretreated with muramyl dipeptide. In CBA mice, a single muramyl dipeptide treatment administered 14, 7, or 4 days before Toxoplasma challenge did not afford protection, whereas mice treated at -1 day were highly resistant. Additional studies carried out to investigate the mechanisms underlying the enhanced resistance to Toxoplasma in muramyl dipeptide-treated mice failed to reveal either enhanced cytolytic antibodies to the parasite or evidence that peritoneal macrophages from treated mice were activated as determined in vitro by their microbicidal capacity for Toxoplasma or cytotoxic capacity for tumor target cells.
摘要
开展了多项研究，以确定用合成佐剂胞壁酰二肽处理小鼠是否能使其对专性细胞内原生动物刚地弓形虫的感染产生任何抗性。在用胞壁酰二肽预处理的CBA小鼠中观察到对致死性攻击感染有显著抗性，但C57BL/6小鼠中未观察到。在CBA小鼠中，在弓形虫攻击前14天、7天或4天进行单次胞壁酰二肽处理未提供保护作用，而在攻击前1天处理的小鼠具有高度抗性。为研究胞壁酰二肽处理的小鼠对弓形虫抗性增强的潜在机制而开展的其他研究，未能揭示对该寄生虫的溶细胞抗体增强，也未发现证据表明处理过的小鼠的腹腔巨噬细胞通过其对弓形虫的杀菌能力或对肿瘤靶细胞的细胞毒性能力在体外测定时被激活。
相似文献
1
Effects of muramyl dipeptide treatment on resistance to infection with Toxoplasma gondii in mice.胞壁酰二肽处理对小鼠抗弓形虫感染能力的影响。
Infect Immun. 1981 Feb;31(2):716-22. doi: 10.1128/iai.31.2.716-722.1981.
2
Effects of treatment with muramyl dipeptide and certain of its analogs on resistance to Listeria monocytogenes in mice.用胞壁酰二肽及其某些类似物治疗对小鼠抗单核细胞增生李斯特菌能力的影响。
Infect Immun. 1980 Nov;30(2):462-6. doi: 10.1128/iai.30.2.462-466.1980.
3
Effects of muramyl dipeptide and trehalose dimycolate on resistance of mice to Toxoplasma gondii and Acanthamoeba culbertsoni infections.胞壁酰二肽和海藻糖二霉菌酸酯对小鼠抵抗刚地弓形虫和卡氏棘阿米巴感染的影响。
Int Arch Allergy Appl Immunol. 1986;81(2):112-7. doi: 10.1159/000234118.
4
Comparison of cytotoxic and microbicidal function of bronchoalveolar and peritoneal macrophages.支气管肺泡巨噬细胞和腹腔巨噬细胞的细胞毒性及杀菌功能比较
Immunology. 1981 Apr;42(4):513-9.
5
In vivo regulation of humoral and cellular immune responses of mice by a synthetic adjuvant, N-acetyl-muramyl-L-alanyl-D-isoglutamine, muramyl dipeptide for MDP.合成佐剂N-乙酰-胞壁酰-L-丙氨酰-D-异谷氨酰胺（胞壁酰二肽，简称MDP）对小鼠体液免疫和细胞免疫反应的体内调节作用
Cell Immunol. 1979 Jun;45(1):199-206. doi: 10.1016/0008-8749(79)90377-0.
6
Immunoadjuvant effects of the synthetic muramyl-dipeptide (MDP) N-acetylmuramyl-L-alanyl-D-isoglutamine.合成的胞壁酰二肽（MDP）N-乙酰胞壁酰-L-丙氨酰-D-异谷氨酰胺的免疫佐剂作用。
Z Immunitatsforsch Immunobiol. 1978 Oct;155(1):87-92.
7
Recent developments concerning muramyl dipeptide, a synthetic immunoregulating molecule.关于胞壁酰二肽（一种合成免疫调节分子）的最新进展。
J Reticuloendothel Soc. 1979 Dec;26(Suppl):631-41.
8
Marked enhancement in vivo of adjuvant activity of muramyl dipeptide to protein antigens and to synthetic weak immunogens with monoclonal anti-muramyl dipeptide antibodies.用单克隆抗胞壁酰二肽抗体在体内显著增强胞壁酰二肽对蛋白质抗原和合成弱免疫原的佐剂活性。
Infect Immun. 1985 Aug;49(2):312-9. doi: 10.1128/iai.49.2.312-319.1985.
9
Activation of mouse peritoneal adherent cells with N-acyl muramyl dipeptide derivatives.用N-酰基胞壁酰二肽衍生物激活小鼠腹膜黏附细胞。
Infect Immun. 1985 Mar;47(3):665-9. doi: 10.1128/iai.47.3.665-669.1985.
10
Protective effect of muramyl dipeptide analogs against infections of Pseudomonas aeruginosa or Candida albicans in mice.胞壁酰二肽类似物对小鼠铜绿假单胞菌或白色念珠菌感染的保护作用。
Infect Immun. 1981 Dec;34(3):676-83. doi: 10.1128/iai.34.3.676-683.1981.
引用本文的文献
1
The cat's out of the bag: Toxoplasma gondii provides further insight into myeloid-mediated host defense.真相大白：刚地弓形虫为髓系介导的宿主防御提供了进一步的见解。
Immunohorizons. 2025 Aug 25;9(9). doi: 10.1093/immhor/vlaf037.
2
Trained immunity: novel perspectives in diabetes and associated complications.训练有素的免疫：糖尿病及相关并发症的新视角。
Front Immunol. 2025 Jul 17;16:1613602. doi: 10.3389/fimmu.2025.1613602. eCollection 2025.
3
Immunization with Complete Freund's Adjuvant Reveals Trained Immunity-like Features in A/J Mice.用完全弗氏佐剂免疫揭示了A/J小鼠中类似训练免疫的特征。
Vaccines (Basel). 2025 Jul 21;13(7):768. doi: 10.3390/vaccines13070768.
4
Repeated and alternate stimulations with dsRNA and SEB alter responses in macrophages and epithelial cells.用双链RNA和葡萄球菌肠毒素B重复交替刺激会改变巨噬细胞和上皮细胞的反应。
World Allergy Organ J. 2025 Jan 24;18(2):101026. doi: 10.1016/j.waojou.2025.101026. eCollection 2025 Feb.
5
Role of Trained Immunity in Heath and Disease.训练有素的免疫在健康与疾病中的作用。
Curr Cardiol Rep. 2025 Jan 13;27(1):18. doi: 10.1007/s11886-024-02167-7.
6
Infection-induced trained immunity: a twist in paradigm of innate host defense and generation of immunological memory.感染诱导的训练免疫：固有宿主防御范式的转变与免疫记忆的产生。
Infect Immun. 2025 Jan 31;93(1):e0047224. doi: 10.1128/iai.00472-24. Epub 2024 Dec 10.
7
Induction of trained immunity in broiler chickens following delivery of oligodeoxynucleotide containing CpG motifs to protect against Escherichia coli septicemia.经 CpG 基序寡脱氧核苷酸给药诱导肉鸡产生训练性免疫以预防大肠杆菌败血病。
Sci Rep. 2024 Aug 14;14(1):18882. doi: 10.1038/s41598-024-69781-x.
8
Type-I interferons promote innate immune tolerance in macrophages exposed to Mycobacterium ulcerans vesicles.I 型干扰素促进分枝杆菌囊泡暴露的巨噬细胞固有免疫耐受。
PLoS Pathog. 2023 Jul 10;19(7):e1011479. doi: 10.1371/journal.ppat.1011479. eCollection 2023 Jul.
9
Trained innate immunity, epigenetics, and food allergy.训练有素的固有免疫、表观遗传学与食物过敏。
Front Allergy. 2023 May 26;4:1105588. doi: 10.3389/falgy.2023.1105588. eCollection 2023.
10
The mechanisms and cross-protection of trained innate immunity.训练有素的先天免疫的机制和交叉保护。
Virol J. 2022 Dec 8;19(1):210. doi: 10.1186/s12985-022-01937-5.
本文引用的文献
1
Effects of treatment with muramyl dipeptide and certain of its analogs on resistance to Listeria monocytogenes in mice.用胞壁酰二肽及其某些类似物治疗对小鼠抗单核细胞增生李斯特菌能力的影响。
Infect Immun. 1980 Nov;30(2):462-6. doi: 10.1128/iai.30.2.462-466.1980.
2
Effects of human peripheral blood monocytes, monocyte-derived macrophages, and spleen mononuclear phagocytes on Toxoplasma gondii.人外周血单核细胞、单核细胞衍生巨噬细胞和脾单核吞噬细胞对刚地弓形虫的作用。
Cell Immunol. 1980 Sep 1;54(2):330-50. doi: 10.1016/0008-8749(80)90214-2.
3
Immunostimulant activities of a lipophilic muramyl dipeptide derivative and of desmuramyl peptidolipid analogs.一种亲脂性胞壁酰二肽衍生物和去胞壁酰肽脂类似物的免疫刺激活性。
Infect Immun. 1980 Mar;27(3):826-31. doi: 10.1128/iai.27.3.826-831.1980.
4
Serological and immunochemical characterization of monoclonal antibodies to Toxoplasma gondii.抗刚地弓形虫单克隆抗体的血清学及免疫化学特性分析
Immunology. 1980 Aug;40(4):579-88.
5
Cytostatic effects of activated macrophages on tumor target cells: inhibition of cytotoxic action of ARA-C.活化巨噬细胞对肿瘤靶细胞的细胞生长抑制作用：阿糖胞苷细胞毒性作用的抑制
J Immunopharmacol. 1980;2(3):325-48. doi: 10.3109/08923978009046465.
6
Macrophage stimulation in vitro by an inactive muramyl dipeptide derivative after conjugation to a multi-poly(DL-alanyl)-poly(L-lysine) carrier.与多聚（DL-丙氨酰）-聚（L-赖氨酸）载体偶联后，一种无活性的胞壁酰二肽衍生物在体外对巨噬细胞的刺激作用。
Infect Immun. 1980 Apr;28(1):1-5. doi: 10.1128/iai.28.1.1-5.1980.
7
Failure of synthetic muramyl dipeptide to increase antibacterial resistance.合成的胞壁酰二肽未能增加抗菌抗性。
Infect Immun. 1980 Feb;27(2):288-91. doi: 10.1128/iai.27.2.288-291.1980.
8
The influence of immunologically committed lymphoid cells on macrophage activity in vivo.免疫致敏淋巴细胞对体内巨噬细胞活性的影响。
J Exp Med. 1969 May 1;129(5):973-92. doi: 10.1084/jem.129.5.973.
9
Scanning electron microscopy of Toxoplasma gondii.刚地弓形虫的扫描电子显微镜检查
J Gen Microbiol. 1973 Mar;75(1):111-8. doi: 10.1099/00221287-75-1-111.
10
A role for activated macrophages in resistance to infection with Toxoplasma.活化巨噬细胞在抵抗弓形虫感染中的作用。
Infect Immun. 1972 Nov;6(5):829-34. doi: 10.1128/iai.6.5.829-834.1972.
Zotero 插件