Wu Chao, Yu Chenyang, Yang Yuyan, Jin Hongzhong
Department of Dermatology, State Key Laboratory of Complex Severe and Rare Diseases, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, National Clinical Research Center for Dermatologic and Immunologic Diseases, Beijing, China.
Front Cardiovasc Med. 2023 Aug 1;10:1169474. doi: 10.3389/fcvm.2023.1169474. eCollection 2023.
Erythrodermic psoriasis (EP) is a severe form of psoriasis that affects multiple organs, including the cardiovascular system. However, few studies have focused on this condition.This study is aimed to assess the prevalence and factors associated with heart failure in EP patient, and to the measure the serum concentrations of fibroblast growth factor 23 (FGF23), a potential predictor of chronic heart failure.
We retrospectively studied patients with EP hospitalized at Peking Union Medical College Hospital between January 2005 to October 2021. The prevalence of heart failure and associated factors was measured. In addition, peripheral blood samples were collected from 17 patients and matched with samples from eight healthy controls, and their serum concentrations of FGF23 were measured by ELISA.
We studied 225 patients with EP, with a male: female ratio of 2.7:1 and a mean age of 47.6 ± 16.7 years. Twenty-five (11.1%) participants were diagnosed with heart failure during their hospital stay. The patients with EP and heart failure were older (58.2 years vs. 46.2 years, = 0.001); had a higher prevalence of a history of coronary heart disease (32.0% vs. 21.5%, < 0.001), fever (48.0% vs. 23.0%, = 0.007), infection (56.0% vs. 35.5%, = 0.046); higher hsCRP concentration (43.2 mg/L vs. 8.2 mg/L, = 0.005); and higher prevalence of anemia (60.0% vs. 22.0%, < 0.001), hypoalbuminemia (64.0% vs. 42.0%, = 0.037), and hyperlipidemia (40.0% vs. 20.0%, = 0.023) than those without heart failure. The serum FGF23 concentration was significantly higher in patients with EP than controls (493.1 pg/ml vs. 277.8 pg/ml, = 0.027), and was significantly lower after treatment (395.7 pg/ml vs. 463.1 pg/ml, = 0.022).
Clinicians should be aware of the risk of heart failure in patients with EP, and especially those of advanced age and with a history of coronary heart disease, severe systemic symptoms, high concentrations of inflammatory biomarkers, and poor nutritional status.
红皮病型银屑病（EP）是银屑病的一种严重形式，可累及包括心血管系统在内的多个器官。然而，针对这种情况的研究较少。本研究旨在评估EP患者心力衰竭的患病率及相关因素，并测定成纤维细胞生长因子23（FGF23）的血清浓度，FGF23是慢性心力衰竭的一个潜在预测指标。
我们回顾性研究了2005年1月至2021年10月在北京协和医院住院的EP患者。测定心力衰竭的患病率及相关因素。此外，采集了17例患者的外周血样本，并与8例健康对照的样本进行匹配，采用酶联免疫吸附测定法（ELISA）测定他们血清中FGF23的浓度。
我们研究了225例EP患者，男女比例为2.7:1，平均年龄为47.6±16.7岁。25例（11.1%）参与者在住院期间被诊断为心力衰竭。EP合并心力衰竭的患者年龄更大（58.2岁对46.2岁，P = 0.001）；冠心病病史的患病率更高（32.0%对21.5%，P < 0.001）、发热（48.0%对23.0%，P = 0.007）、感染（56.0%对35.5%，P = 0.046）；高敏C反应蛋白（hsCRP）浓度更高（43.2mg/L对8.2mg/L，P = 0.005）；贫血（60.0%对22.0%，P < 0.001）、低白蛋白血症（64.0%对42.0%，P = 0.037）和高脂血症（40.0%对20.0%，P = 0.023）的患病率均高于无心力衰竭的患者。EP患者血清FGF23浓度显著高于对照组（493.1pg/ml对277.8pg/ml，P =
