Acharya Yash, Taneja Kashish Kumar, Haldar Jayanta
Antimicrobial Research Laboratory, New Chemistry Unit, Jawaharlal Nehru Centre for Advanced Scientific Research (JNCASR) Jakkur Bengaluru 560064 Karnataka India
School of Advanced Materials, Jawaharlal Nehru Centre for Advanced Scientific Research (JNCASR) Jakkur Bengaluru 560064 Karnataka India.
RSC Med Chem. 2023 May 24;14(8):1410-1428. doi: 10.1039/d3md00166k. eCollection 2023 Aug 16.
The emergence of antimicrobial resistance, coupled with the occurrence of persistent systemic infections, has already complicated clinical therapy efforts. Moreover, infections are also accompanied by strong inflammatory responses, generated by the host's innate and adaptive immune systems. The closely intertwined relationship between bacterial infection and inflammation has multiple implications on the ability of antibacterial therapeutics to tackle infection and inflammation. Particularly, uncontrolled inflammatory responses to infection can lead to sepsis, a life-threatening physiological condition. In this review, we discuss dual-functional antibacterial therapeutics that have potential to be developed for treating inflammation associated with bacterial infections. Immense research is underway that aims to develop new therapeutic agents that, when administered, regulate the excess inflammatory response, they have immunomodulatory properties along with the desired antibacterial activity. The classes of antibiotics that have immunomodulatory function in addition to antibacterial activity have been reviewed. Host defense peptides and their synthetic mimics are amongst the most sought-after solutions to develop such dual-functional therapeutics. This review also highlights the important classes of peptidomimetics that exhibit both antibacterial and immunomodulatory properties.
抗菌药物耐药性的出现，再加上持续性全身感染的发生，已经使临床治疗工作变得复杂。此外，感染还伴随着由宿主先天和适应性免疫系统产生的强烈炎症反应。细菌感染与炎症之间紧密交织的关系对抗菌治疗应对感染和炎症的能力具有多重影响。特别是，对感染的不受控制的炎症反应可导致脓毒症，这是一种危及生命的生理状况。在本综述中，我们讨论了有可能被开发用于治疗与细菌感染相关炎症的双功能抗菌疗法。目前正在进行大量研究，旨在开发新的治疗药物，这些药物在给药时能调节过度的炎症反应，它们具有免疫调节特性以及所需的抗菌活性。除抗菌活性外还具有免疫调节功能的抗生素类别已被综述。宿主防御肽及其合成模拟物是开发此类双功能疗法最受追捧的解决方案之一。本综述还强调了兼具抗菌和免疫调节特性的重要肽模拟物类别。
