COVID-19 还是癌症压力？晚期肺癌患者的焦虑和抑郁症状。

COVID-19 or Cancer Stress? Anxiety and Depressive Symptoms in Patients with Advanced Lung Cancer.

机构信息

Department of Psychology, The Ohio State University, 1835 Neil Avenue, Columbus, OH, 43210, USA.

Comprehensive Cancer Center, The Ohio State University, 1835 Neil Avenue, Columbus, OH, 43210, USA.

出版信息

Int J Behav Med. 2024 Apr;31(2):325-330. doi: 10.1007/s12529-023-10206-w. Epub 2023 Aug 18.

DOI:10.1007/s12529-023-10206-w

PMID:37594667

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11271711/

Abstract

BACKGROUND

Of all cancer patients, those with lung cancer are among the highest risk for infection, pneumonia, hospitalization, and early death from COVID-19. As cancer stress is ubiquitous, this exploratory study examines patients' COVID-19 stress and cancer stress in relation to their depressive and anxiety symptoms.

METHOD

Newly diagnosed advanced lung cancer patients (N = 76) completed measures of cancer stress, COVID-19 illness perceptions and stress, and depressive and anxiety symptoms at a single monthly follow-up early in the pandemic (May 2020 to July 2020; Clinicaltrials.gov #NCT03199651). Hierarchical linear multiple regression analysis was used to identify the relationship of stressor variables to depressive and anxiety symptoms in this cross-sectional study.

RESULTS

Hierarchical linear models revealed cancer stress was a significant predictor of both depressive symptoms (F(14,30) = 5.327, p < 0.001, R = 0.71, adjusted R = 0.58) and anxiety symptoms (F(14,30) = 4.513, p < 0.001, R = 0.68, adjusted R = 0.53) for patients at the start of the COVID-19 pandemic. By contrast, COVID-19 stress was not a significant predictor of depressive (F(13,31) = 1.415 p = .21, R = .37, adjusted R = .11) or anxiety symptoms (F(13,31) = 1.23, p = .30, R = .34, adjusted R = - .07).

CONCLUSIONS

Advanced lung cancer patients during the early phase of the COVID-19 pandemic reported cancer stress as more important than COVID-19 stress in relation to their mental health. Empirically supported biobehavioral and cognitive behavioral treatments remain important to reducing psychological symptoms and enhancing patients' quality of life.

摘要

背景

在所有癌症患者中，肺癌患者感染新冠病毒、患肺炎、住院和因新冠病毒而早期死亡的风险最高。由于癌症带来的压力普遍存在，这项探索性研究调查了患者的新冠病毒相关压力和癌症压力与其抑郁和焦虑症状的关系。

方法

在新冠疫情早期（2020 年 5 月至 7 月），新诊断为晚期肺癌的患者（N=76）在每月一次的随访中完成了癌症压力、新冠病毒疾病认知和压力、抑郁和焦虑症状的评估。（Clinicaltrials.gov #NCT03199651）。在这项横断面研究中，采用分层线性多元回归分析来确定应激源变量与抑郁和焦虑症状的关系。

结果

分层线性模型显示，癌症压力是患者在新冠疫情开始时抑郁症状（F(14,30)=5.327，p<0.001，R=0.71，调整后的 R=0.58）和焦虑症状（F(14,30)=4.513，p<0.001，R=0.68，调整后的 R=0.53）的显著预测因子。相比之下，新冠病毒相关压力并不是抑郁症状（F(13,31)=1.415，p=0.21，R=0.37，调整后的 R=0.11）或焦虑症状（F(13,31)=1.23，p=0.30，R=0.34，调整后的 R=−0.07）的显著预测因子。