Seuter F, Busse W D, Meng K, Hoffmeister F, Möller E, Horstmann H
Arzneimittelforschung. 1979;29(1):54-9.
The activity of 1-[2-(beta-naphthyloxy)ethyl]-3-methyl-2-pyrazolin-5-one (= BAY g 6575) was evaluated in models of experimental thrombosis caused by traumatically induced damage of vessel segments. After prophylactic administration of BAY g 6575 (0.3 mg/kg p.o.) to rats the thrombus formation was significantly reduced in the carotid artery as well as in the jugular vein. The thrombus formation in the femoral arteries of rabbits is inhibited at a minimal effective dose of 1 mg/kg p.o. The incidence of occlusive thrombi is not influenced. BAY g 6575 is 10 times more potent than acetylsalicylic acid (ASA). In the arterial system the thrombus formation is frequently completely abolished.
在因创伤性损伤血管段所致的实验性血栓形成模型中，对1-[2-(β-萘氧基)乙基]-3-甲基-2-吡唑啉-5-酮（=BAY g 6575）的活性进行了评估。给大鼠预防性口服BAY g 6575（0.3毫克/千克）后，颈动脉和颈静脉中的血栓形成显著减少。兔股动脉中的血栓形成在口服最小有效剂量1毫克/千克时受到抑制。闭塞性血栓的发生率未受影响。BAY g 6575的效力比乙酰水杨酸（ASA）强10倍。在动脉系统中，血栓形成常常被完全消除。
