非 O1/O139 霍乱弧菌和鼠伤寒沙门氏菌的种间相互作用：一例罕见的合并感染病例报告。
Interspecies interactions of non-O1/O139 Vibrio cholerae and Salmonella typhimurium: a rare coinfection case report.
机构信息
Department of Clinical Laboratory, Affiliated Hospital 6 of Nantong University, Yancheng Third People's Hospital, Yancheng, Jiangsu, China.
Department of Clinical Laboratory, Henan Provincial People's Hospital, Department of Clinical Laboratory of Central China Fuwai Hospital, Central China Fuwai Hospital of Zhengzhou University, Zhengzhou, Henan, China.
出版信息
Diagn Microbiol Infect Dis. 2023 Nov;107(3):116049. doi: 10.1016/j.diagmicrobio.2023.116049. Epub 2023 Aug 4.
Infectious diseases are commonly demonstrated to be caused by polymicrobial infections, which correlate with increased infection severity and poorer clinical outcomes. In this study, we report a rare intestinal coinfection case of non-O1/O139 Vibrio cholerae and Salmonella typhimurium, along with V. cholerae septicemia. The data of quantitative real-time PCR and competition assay showed that V. cholerae may present enhanced virulence in the presence of S. typhimurium, and exerted an inhibitory growth effect over S. typhimurium in vitro.
传染病通常被证明是由多种微生物感染引起的，这与感染的严重程度增加和临床预后较差有关。在本研究中，我们报告了一例罕见的霍乱弧菌和鼠伤寒沙门氏菌非 O1/O139 型肠双重感染病例，以及霍乱弧菌败血症。实时荧光定量 PCR 和竞争试验数据显示，霍乱弧菌在存在鼠伤寒沙门氏菌的情况下可能表现出增强的毒力，并在体外对鼠伤寒沙门氏菌表现出抑制生长作用。
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