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Tnni3k 影响心肌细胞 S 期活性和增殖。

Tnni3k influences cardiomyocyte S-phase activity and proliferation.

机构信息

Department of Cell Biology, Neurobiology, and Anatomy, Medical College of Wisconsin, Milwaukee, WI, United States of America.

Department of Regenerative Medicine and Cell Biology, Medical University of South Carolina, Charleston, SC, United States of America.

出版信息

J Mol Cell Cardiol. 2023 Oct;183:22-26. doi: 10.1016/j.yjmcc.2023.08.004. Epub 2023 Aug 17.

DOI:10.1016/j.yjmcc.2023.08.004
PMID:37597489
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11645536/
Abstract

Cardiomyocyte proliferation is a difficult phenomenon to capture and prove. Here we employ a retrospective analysis of single cell ventricular suspensions to definitively identify cardiomyocytes that have completed cell division. Through this analysis we determined that the capacity of cardiomyocytes to re-enter the cell cycle and complete cell division after injury are separate and variable traits. Further, we provide evidence that Tnni3k definitively influences both early and final stages of the cell cycle.

摘要

心肌细胞增殖是一种难以捕捉和证明的现象。在这里，我们采用单细胞心室悬浮液的回顾性分析，明确鉴定已完成细胞分裂的心肌细胞。通过这项分析，我们确定了心肌细胞在损伤后重新进入细胞周期并完成细胞分裂的能力是两个独立且可变的特征。此外，我们提供的证据表明 Tnni3k 确实会影响细胞周期的早期和晚期阶段。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/16f8/11645536/8e14833f40d7/nihms-2040773-f0002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/16f8/11645536/8e14833f40d7/nihms-2040773-f0002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/16f8/11645536/8e14833f40d7/nihms-2040773-f0002.jpg

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本文引用的文献

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Development. 2023 Apr 1;150(7). doi: 10.1242/dev.201318. Epub 2023 Apr 13.
2
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Circulation. 2023 Jan 10;147(2):142-153. doi: 10.1161/CIRCULATIONAHA.122.061130. Epub 2022 Nov 16.
3
Measuring cardiomyocyte cell-cycle activity and proliferation in the age of heart regeneration.测量心脏再生时代的心肌细胞细胞周期活动和增殖。
Am J Physiol Heart Circ Physiol. 2022 Apr 1;322(4):H579-H596. doi: 10.1152/ajpheart.00666.2021. Epub 2022 Feb 18.
4
Cell proliferation fate mapping reveals regional cardiomyocyte cell-cycle activity in subendocardial muscle of left ventricle.细胞增殖命运图谱揭示左心室心内膜下心肌的区域性心肌细胞周期活性。
Nat Commun. 2021 Oct 1;12(1):5784. doi: 10.1038/s41467-021-25933-5.
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Dynamic Transcriptional Responses to Injury of Regenerative and Non-regenerative Cardiomyocytes Revealed by Single-Nucleus RNA Sequencing.单核RNA测序揭示再生和非再生心肌细胞损伤的动态转录反应
Dev Cell. 2020 Dec 7;55(5):665-667. doi: 10.1016/j.devcel.2020.11.006.
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