School of Pharmaceutical Sciences, South-Central Minzu University, Wuhan, 430074, China.
State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming, 650201, China.
Phytochemistry. 2023 Oct;214:113830. doi: 10.1016/j.phytochem.2023.113830. Epub 2023 Aug 18.
Four previously undescribed chamigrane sesquiterpenes, namely steccherins A-D, have been isolated from the fungus Steccherinum ochraceum. Their structures were elucidated by extensive spectroscopic analysis, as well as computational methods and single crystal X-ray diffraction. Steccherins A and B possess previously undescribed backbones which might be derived from normal chamigrane sesquiterpenes, especially that steccherin A possesses a spiro[5.6]dodecane carbon skeleton via a ring-rearrangement. Steccherins A, C, and D showed immunosuppressive activity with IC values ranging from 6.2 to 37.8 μM. The data suggested that these chamigrane sesquiterpenes have potential selective inhibition on LPS-induced B lymphocyte proliferation.
四种先前未被描述的 chamigrane 倍半萜，即 steccherins A-D，已从真菌 Steccherinum ochraceum 中分离出来。通过广泛的光谱分析以及计算方法和单晶 X 射线衍射，阐明了它们的结构。Steccherins A 和 B 具有以前未描述的骨架，可能来自于正常的 chamigrane 倍半萜，特别是 steccherin A 通过环重排具有 spiro[5.6]dodecane 碳骨架。Steccherins A、C 和 D 表现出免疫抑制活性，IC 值范围为 6.2 至 37.8 μM。数据表明，这些 chamigrane 倍半萜对 LPS 诱导的 B 淋巴细胞增殖具有潜在的选择性抑制作用。
