Department of Medical Laboratory Sciences, Faculty of Health Sciences and Technology, College of Medicine, University of Nigeria, Enugu Campus, Nigeria.
Department of Medical Biochemistry, Faculty of Basic Medical Sciences, College of Medicine, University of Nigeria, Enugu Campus, Nigeria.
Pak J Pharm Sci. 2023 Jul;36(4):1121-1126.
The protective effects of the leaf powder of Picralima nitida in male rats were evaluated to establish its haematopoietic potential. To achieve this, albino rats (n = 30), weighing 120 - 160g were grouped into 5, labelled A to E. Groups C and D were intraperitoneally induced for anaemia with 0.1mg/kg body weight (b.wt) of phenyl hydrazine for 7 day. Groups A and B and C and D orally received 200 and 400 mg/kg b.wt of Picralima nitida leaf extract respectively for 14 days. Group E served as the control. Blood sample (5.0ml) was collected from each rat on days 8 and 15 and dispensed into ethylene diamine tetra acetic acid containers for haemogram using haematology auto analyser. The result showed that on day 8, Picralima nitida leaf extract produced a significant (P<0.05) increase in haemoglobin (Hb) and haematocrit (Hct) when compared with the control. On day 15, Picralima nitida leaf extract produced a significant (P<0.05) increase in the red blood cell (RBC), Hb and Hct when compared with the experimental control. The results indicate time-dependent haematopoiesis.
为了评估 Picralima nitida 叶粉对雄性大鼠的保护作用，以确定其造血潜能。为此，将 30 只体重为 120-160g 的白化大鼠(n=30)分为 5 组，分别标记为 A 至 E。第 C 组和第 D 组通过腹腔注射 0.1mg/kg 体重的苯肼诱导贫血，共 7 天。第 A 组和第 B 组及第 C 组和第 D 组分别口服 200 和 400mg/kg 体重的 Picralima nitida 叶提取物，共 14 天。第 E 组作为对照。第 8 天和第 15 天，从每组大鼠采集 5.0ml 血样，并置于乙二胺四乙酸容器中，使用血液自动分析仪进行血常规检查。结果表明，与对照组相比，Picralima nitida 叶提取物在第 8 天显著增加了血红蛋白(Hb)和血细胞比容(Hct)(P<0.05)。第 15 天，与实验对照组相比，Picralima nitida 叶提取物显著增加了红细胞(RBC)、Hb 和 Hct(P<0.05)。结果表明，这是一种时间依赖性的造血作用。
