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Construction of a cell-based aggregation and seeding model for the Tau protein.

作者信息

Hu Jiying, Wang Liqiang, Chen Jie, Liang Yi

机构信息

Hubei Key Laboratory of Cell Homeostasis, College of Life Sciences, TaiKang Center for Life and Medical Sciences, Wuhan University, Wuhan 430072, China.

Office of Core Facility, Shenzhen Bay Laboratory, Shenzhen 518000, China.

出版信息

Acta Biochim Biophys Sin (Shanghai). 2024 Apr 29;56(7):1085-1088. doi: 10.3724/abbs.2024057.

DOI:10.3724/abbs.2024057
PMID:38682159
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11322869/
Abstract
摘要
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/252c/11322869/a32fc61a98c1/abbs-2023-542-t3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/252c/11322869/c4ec986a2511/abbs-2023-542-t1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/252c/11322869/9e543f49b67e/abbs-2023-542-t2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/252c/11322869/a32fc61a98c1/abbs-2023-542-t3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/252c/11322869/c4ec986a2511/abbs-2023-542-t1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/252c/11322869/9e543f49b67e/abbs-2023-542-t2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/252c/11322869/a32fc61a98c1/abbs-2023-542-t3.jpg

相似文献

1
Construction of a cell-based aggregation and seeding model for the Tau protein.构建基于细胞的Tau蛋白聚集与接种模型。
Acta Biochim Biophys Sin (Shanghai). 2024 Apr 29;56(7):1085-1088. doi: 10.3724/abbs.2024057.
2
Comparison of size distribution and (Pro249-Ser258) epitope exposure in in vitro and in vivo derived Tau fibrils.比较体外和体内来源的 Tau 纤维中大小分布和(Pro249-Ser258)表位暴露情况。
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J Biol Chem. 2018 Feb 16;293(7):2408-2421. doi: 10.1074/jbc.M117.815357. Epub 2017 Dec 19.
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Conformation determines the seeding potencies of native and recombinant Tau aggregates.构象决定天然和重组 Tau 聚集体的种子形成能力。
J Biol Chem. 2015 Jan 9;290(2):1049-65. doi: 10.1074/jbc.M114.589309. Epub 2014 Nov 18.
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Int J Mol Sci. 2021 Jun 7;22(11):6132. doi: 10.3390/ijms22116132.
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本文引用的文献

1
FMRI Complexity Correlates with Tau-PET and Cognitive Decline in Late-Onset and Autosomal Dominant Alzheimer's Disease.功能磁共振复杂度与晚发性和常染色体显性阿尔茨海默病的 Tau-PET 和认知下降相关。
J Alzheimers Dis. 2023;95(2):437-451. doi: 10.3233/JAD-220851.
2
Zinc enhances liquid-liquid phase separation of Tau protein and aggravates mitochondrial damages in cells.锌增强了 Tau 蛋白的液-液相分离,并加重细胞中的线粒体损伤。
Int J Biol Macromol. 2022 Jun 1;209(Pt A):703-715. doi: 10.1016/j.ijbiomac.2022.04.034. Epub 2022 Apr 9.
3
Myricetin slows liquid-liquid phase separation of Tau and activates ATG5-dependent autophagy to suppress Tau toxicity.
杨梅素可减缓 Tau 的液-液相分离,并激活 ATG5 依赖性自噬以抑制 Tau 毒性。
J Biol Chem. 2021 Oct;297(4):101222. doi: 10.1016/j.jbc.2021.101222. Epub 2021 Sep 22.
4
Fate and propagation of endogenously formed Tau aggregates in neuronal cells.内源性形成的 Tau 聚集物在神经元细胞中的命运和传播。
EMBO Mol Med. 2020 Dec 7;12(12):e12025. doi: 10.15252/emmm.202012025. Epub 2020 Nov 12.
5
Tau PET in autosomal dominant Alzheimer's disease: relationship with cognition, dementia and other biomarkers.tau PET 于常染色体显性阿尔茨海默病:与认知、痴呆和其他生物标志物的关系。
Brain. 2019 Apr 1;142(4):1063-1076. doi: 10.1093/brain/awz019.
6
What is the evidence that tau pathology spreads through prion-like propagation?tau 病理学是否通过类朊病毒传播而扩散的证据是什么?
Acta Neuropathol Commun. 2017 Dec 19;5(1):99. doi: 10.1186/s40478-017-0488-7.
7
Propagation of Tau Aggregates and Neurodegeneration.tau 聚集物的传播与神经退行性变。
Annu Rev Neurosci. 2017 Jul 25;40:189-210. doi: 10.1146/annurev-neuro-072116-031153.
8
Tau and tauopathies.tau蛋白与tau蛋白病
Brain Res Bull. 2016 Sep;126(Pt 3):238-292. doi: 10.1016/j.brainresbull.2016.08.018. Epub 2016 Sep 9.
9
Heterotypic seeding of Tau fibrillization by pre-aggregated Abeta provides potent seeds for prion-like seeding and propagation of Tau-pathology in vivo.预先聚集的β-淀粉样蛋白对Tau蛋白纤维化的异型播种为体内Tau病理的朊病毒样播种和传播提供了有效的种子。
Acta Neuropathol. 2016 Apr;131(4):549-69. doi: 10.1007/s00401-015-1525-x. Epub 2016 Jan 6.
10
Extracellular monomeric tau protein is sufficient to initiate the spread of tau protein pathology.细胞外单体tau蛋白足以引发tau蛋白病理学的传播。
J Biol Chem. 2014 Jan 10;289(2):956-67. doi: 10.1074/jbc.M113.515445. Epub 2013 Nov 14.