Yin Shan, Yang Zhenzhen, Zhu Pingyu, Du Zhongbo, Yu Xiaodong, Tang Tielong, Borné Yan
Department of Urology, Affiliated Hospital of North Sichuan Medical College, Nanchong, China.
Department of Clinical Laboratory, Nanchong Central Hospital, Nanchong, China.
Front Nutr. 2023 Aug 4;10:1226082. doi: 10.3389/fnut.2023.1226082. eCollection 2023.
Added sugar is associated with a variety of adverse health outcomes, but its association with kidney stones is unclear. This study was to determine whether added sugar is associated with kidney stones.
This nationally representative study used National Health and Nutrition Examination Survey (NHANES) datasets from 2007 to 2018 for analysis. People aged ≥20 years who reported a history of kidney stones and provided dietary recall data on added sugars were included. Weighted proportions, multivariable logistic regression analysis and stratified logistic regression were used to evaluate the associations between added sugars and kidney stones by adjusting potential confounders.
Totally 28,303 adults were included, with weighted mean age [95% confidence interval (CI)] of 48.03 (47.56, 48.51) years, 47.74% (47.09, 48.40%) males and 52.26% (51.60, 52.91%) females. The overall mean (95% CI) energy intake from added sugars was 272.10 (266.59, 277.60) kilocalories. In the fully-adjusted multivariable model, the percentage of energy intake from added sugars was positively correlated with kidney stones. Compared to the first quartile of added sugar energy intake percentage, the population in the fourth quartile had a higher prevalence of kidney stones (OR = 1.39; 95% CI 1.17 to 1.65). Compared with the less than 5% calories from added sugar population, the more than or equal to 25% calories from added sugar had a higher kidney stone prevalence (OR = 1.88; 95% CI 1.52 to 2.32).
A higher percentage of energy intake from added sugars is significantly associated with a higher prevalence of kidney stones. This study provides cross-sectional evidence for the relationship between added sugars and health outcomes.
添加糖与多种不良健康结局相关，但其与肾结石的关联尚不清楚。本研究旨在确定添加糖是否与肾结石有关。
这项具有全国代表性的研究使用了2007年至2018年的国家健康与营养检查调查（NHANES）数据集进行分析。纳入年龄≥20岁且报告有肾结石病史并提供了添加糖饮食回忆数据的人群。采用加权比例、多变量逻辑回归分析和分层逻辑回归，通过调整潜在混杂因素来评估添加糖与肾结石之间的关联。
共纳入28303名成年人，加权平均年龄[95%置信区间（CI）]为48.03（47.56，48.51）岁，男性占47.74%（47.09，48.40%），女性占52.26%（51.60，52.91%）。添加糖的总体平均（95%CI）能量摄入量为272.10（266.59，277.60）千卡。在完全调整的多变量模型中，添加糖的能量摄入百分比与肾结石呈正相关。与添加糖能量摄入百分比的第一个四分位数相比，第四个四分位数的人群肾结石患病率更高（OR = 1.39；95%CI为1.17至1.65）。与添加糖热量低于5%的人群相比，添加糖热量大于或等于25%的人群肾结石患病率更高（OR = 1.88；95%CI为1.52至2.32）。
添加糖的能量摄入百分比越高，与肾结石患病率越高显著相关。本研究为添加糖与健康结局之间的关系提供了横断面证据。
