Li Xiao-Ran, Liu Han-Lin, Wang Li, Yang Jian-Wei, Wang Kang-Yu, Chen Si-Yu, Yang Li
The Second Hospital and Clinical Medical School, Lanzhou University, Lanzhou, China.
Cuiying Biomedical Research Center, Lanzhou University Second Hospital, Lanzhou, China.
Front Med (Lausanne). 2025 Mar 6;12:1558628. doi: 10.3389/fmed.2025.1558628. eCollection 2025.
This study examined the association between the Life's Crucial 9 (LC9) score and kidney stone prevalence in U.S. adults.
Using data from the National Health and Nutrition Examination Survey (NHANES) spanning 2007 to 2014, this cross-sectional analysis focused on adult participants with kidney stone onset or recurrence. LC9 scores were divided into four quartiles for analysis. Weighted multivariable logistic regression, restricted cubic spline (RCS) modeling, threshold effect analysis, and subgroup analyses were employed to evaluate the relationship between LC9 scores and kidney stone prevalence.
The study included 24,669 participants with an average age of 46.05 ± 0.34 years and a mean LC9 score of 73.76 ± 0.25. The overall prevalence of kidney stones was 8.45%, while the average recurrence rate stood at 2.96%. Importantly, for each one-point increase in the LC9 score, the incidence of kidney stones dropped by 1.2% (95% CI: 0.979 to 0.997, = 0.014). Compared to the lowest quartile (Q1), the Q4 group exhibited a 0.305-fold higher recurrence rate (95% CI: 0.159 to 0.586, < 0.001). Interaction analysis showed that race and gout significantly influenced the relationship between the LC9 score and kidney stone risk. Additionally, curve fitting and threshold effect analysis demonstrated a nonlinear association between LC9 scores and kidney stone recurrence, with a breakpoint identified at 72.777.
An elevated LC9 score correlates with a lower risk of both kidney stone formation and recurrence. Maintaining an optimal LC9 score could be an effective approach for preventing kidney stones.
本研究探讨了美国成年人的生命关键9分（LC9）得分与肾结石患病率之间的关联。
利用2007年至2014年美国国家健康与营养检查调查（NHANES）的数据，这项横断面分析聚焦于有肾结石发病或复发的成年参与者。LC9得分被分为四个四分位数进行分析。采用加权多变量逻辑回归、受限立方样条（RCS）建模、阈值效应分析和亚组分析来评估LC9得分与肾结石患病率之间的关系。
该研究纳入了24669名参与者，平均年龄为46.05±0.34岁，平均LC9得分为73.76±0.25。肾结石的总体患病率为8.45%，而平均复发率为2.96%。重要的是，LC9得分每增加1分，肾结石的发病率下降1.2%（95%置信区间：0.979至0.997，P = 0.014）。与最低四分位数（Q1）相比，Q4组的复发率高0.305倍（95%置信区间：0.159至0.586，P < 0.001）。交互分析表明，种族和痛风显著影响LC9得分与肾结石风险之间的关系。此外，曲线拟合和阈值效应分析表明LC9得分与肾结石复发之间存在非线性关联，确定的断点为72.777。
LC9得分升高与肾结石形成和复发的风险较低相关。维持最佳的LC9得分可能是预防肾结石的有效方法。
