Vo-Dinh Tuan, Liu Yang, Crawford Bridget M, Wang Hsin-Neng, Yuan Hsiangkuo, Register Janna K, Khoury Christopher G
Fitzpatrick Institute for Photonics, Department of Biomedical Engineering, Department of Chemistry, Duke University, Durham, NC 27708-0281, USA.
J Immunol Sci. 2018;2(1):1-8. doi: 10.29245/2578-3009/2018/1.1104. Epub 2018 Jan 2.
Cancer has been a significant threat to human health with more than eight million deaths each year in the world. There is an urgent need to develop novel methods to improve cancer management. Biocompatible gold nanostars (GNS) with tip-enhanced electromagnetic and optical properties have been developed and applied for multifunctional cancer diagnostics and therapy (theranostics). The GNS platform can be used for multiple sensing, imaging and treatment modalities, such as surface-enhanced Raman scattering, two-photon photoluminescence, magnetic resonance imaging and computed tomography as well as photothermal therapy and immunotherapy. GNS-mediated photothermal therapy combined with checkpoint immunotherapy has been found to reverse tumor-mediated immunosuppression, leading to the treatment of not only primary tumors but also cancer metastasis as well as inducing effective long-lasting immunity, i.e. an anticancer 'vaccine' effect.
癌症一直是对人类健康的重大威胁，全球每年有超过800万人死于癌症。迫切需要开发新的方法来改善癌症治疗。具有尖端增强电磁和光学特性的生物相容性金纳米星（GNS）已被开发并应用于多功能癌症诊断和治疗（诊疗一体化）。GNS平台可用于多种传感、成像和治疗方式，如表面增强拉曼散射、双光子光致发光、磁共振成像和计算机断层扫描，以及光热疗法和免疫疗法。已发现GNS介导的光热疗法与检查点免疫疗法相结合可逆转肿瘤介导的免疫抑制，不仅能治疗原发性肿瘤，还能治疗癌症转移，并诱导有效的持久免疫，即抗癌“疫苗”效应。
