Kyarimpa Christine, Nagawa Christine Betty, Omara Timothy, Odongo Silver, Ssebugere Patrick, Lugasi Solomon Omwoma, Gumula Ivan
Department of Chemistry, Faculty of Science, Kyambogo University, P.O. Box 1, Kampala, Uganda.
Department of Forestry, Biodiversity and Tourism, College of Agricultural and Environmental Sciences, Makerere University, P.O. Box 7062, Kampala, Uganda.
Evid Based Complement Alternat Med. 2023 Aug 12;2023:6878852. doi: 10.1155/2023/6878852. eCollection 2023.
Sexual disorders such as erectile dysfunction (ED), sterility, and sexual inappetence represent some of the complex reproductive challenges that require addressing the underlying causes. The aim of this paper was to systematically synthesize literature on the ethnobotany, phytochemistry, bioactivities, and safety of plants used as remedies for managing sexual dysfunction and infertility, and improving fertility and virility in the EAC. Through an extensive review conducted in multidisciplinary electronic databases, 171 plant species were identified to have been reported for the management of sexual inappetence (i.e., used as aphrodisiacs, 39.4%), ED (35.9%), infertility (18.7%), and increasing fertility (6.0%). The most used plants are , , , , , , and while roots (44.9%), leaves (21.8%), stem and root barks (16.7%) of shrubs (35%), trees (31%), herbs (26%), and climbers (8%) are the preferred organs for making decoctions (69%). The research strides to date indicate that , , , , , , and have been assessed for their bioactivity. The majority (71.4%) of the plants either increased testosterone levels and mounting frequency or elicited prosexual stimulatory effects in male rats. More studies investigating the relevant pharmacological activities (aphrodisiac, fertility, and phosphodiesterase-5 inhibitory activities), safety aspects, responsible compounds, and clinical studies are warranted to establish the pharmacological potential of the unstudied species and elucidate the mechanism of action of the bioactive compounds.
勃起功能障碍（ED）、不育症和性欲减退等性功能障碍是一些复杂的生殖挑战，需要解决其根本原因。本文的目的是系统地综合有关植物的民族植物学、植物化学、生物活性和安全性的文献，这些植物被用作治疗性功能障碍和不孕症以及提高东非共同体地区生育能力和男子气概的药物。通过在多学科电子数据库中进行的广泛检索，已确定有171种植物被报道用于治疗性欲减退（即用作壮阳药，占39.4%）、勃起功能障碍（占35.9%）、不育症（占18.7%）和提高生育能力（占6.0%）。最常用的植物有 、 、 、 、 、 和 ，而灌木（占35%）、树木（占31%）、草本植物（占26%）和攀缘植物（占8%）的根（占44.9%）、叶（占21.8%）、茎和根皮（占16.7%）是制作煎剂（占69%）的首选器官。迄今为止的研究进展表明， 、 、 、 、 、 和 已被评估其生物活性。大多数（71.4%）植物要么提高了睾酮水平和交配频率，要么在雄性大鼠中引起性刺激作用。有必要开展更多研究来调查相关药理活性（壮阳、生育和磷酸二酯酶-5抑制活性）、安全性、活性成分以及临床研究，以确定未研究物种的药理潜力，并阐明生物活性化合物的作用机制。
