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初学者的基底神经节:你需要了解的基本概念及其在运动控制中的作用。

Basal ganglia for beginners: the basic concepts you need to know and their role in movement control.

作者信息

Rocha Gabriel S, Freire Marco A M, Britto André M, Paiva Karina M, Oliveira Rodrigo F, Fonseca Ivana A T, Araújo Dayane P, Oliveira Lucidio C, Guzen Fausto P, Morais Paulo L A G, Cavalcanti José R L P

机构信息

Laboratory of Experimental Neurology, Department of Biomedical Sciences, State University of Rio Grande do Norte, Mossoró, Brazil.

出版信息

Front Syst Neurosci. 2023 Aug 3;17:1242929. doi: 10.3389/fnsys.2023.1242929. eCollection 2023.

Abstract

The basal ganglia are a subcortical collection of interacting clusters of cell bodies, and are involved in reward, emotional, and motor circuits. Within all the brain processing necessary to carry out voluntary movement, the basal nuclei are fundamental, as they modulate the activity of the motor regions of the cortex. Despite being much studied, the motor circuit of the basal ganglia is still difficult to understand for many people at all, especially undergraduate and graduate students. This review article seeks to bring the functioning of this circuit with a simple and objective approach, exploring the functional anatomy, neurochemistry, neuronal pathways, related diseases, and interactions with other brain regions to coordinate voluntary movement.

摘要

基底神经节是细胞体相互作用的皮质下集群,参与奖赏、情感和运动回路。在执行自主运动所需的所有大脑处理过程中,基底核至关重要,因为它们调节皮质运动区域的活动。尽管已经进行了大量研究,但基底神经节的运动回路对许多人来说,尤其是本科生和研究生,仍然很难完全理解。这篇综述文章旨在以一种简单而客观的方法介绍该回路的功能,探讨其功能解剖学、神经化学、神经元通路、相关疾病以及与其他脑区的相互作用,以协调自主运动。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5be3/10435282/1023d94af649/fnsys-17-1242929-g001.jpg

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