Zhang Xixia, Yu Xiaofeng
Department of Otolaryngology Head and Neck Surgery, Shengjing Hospital of China Medical University, Shenyang, China.
Front Pharmacol. 2023 Aug 2;14:1230822. doi: 10.3389/fphar.2023.1230822. eCollection 2023.
Wnt signaling plays an important role in regulating the biological behavior of cancers, and many drugs targeting this signaling have been developed. Recently, a series of research have revealed that Wnt signaling could regulate DNA damage response (DDR) which is crucial for maintaining the genomic integrity in cells and closely related to cancer genome instability. Many drugs have been developed to target DNA damage response in cancers. Notably, different components of the Wnt and DDR pathways are involved in crosstalk, forming a complex regulatory network and providing new opportunities for cancer therapy. Here, we provide a brief overview of Wnt signaling and DDR in the field of cancer research and review the interactions between these two pathways. Finally, we also discuss the possibility of therapeutic agents targeting Wnt and DDR as potential cancer treatment strategies.
Wnt信号通路在调节癌症的生物学行为中发挥着重要作用，并且已经开发出许多针对该信号通路的药物。最近，一系列研究表明，Wnt信号通路可以调节DNA损伤反应（DDR），这对于维持细胞中的基因组完整性至关重要，并且与癌症基因组不稳定性密切相关。已经开发出许多针对癌症中DNA损伤反应的药物。值得注意的是，Wnt和DDR通路的不同成分参与了相互作用，形成了一个复杂的调控网络，并为癌症治疗提供了新的机会。在这里，我们简要概述了癌症研究领域中的Wnt信号通路和DDR，并综述了这两条通路之间的相互作用。最后，我们还讨论了靶向Wnt和DDR的治疗药物作为潜在癌症治疗策略的可能性。
