新斯的明临床应用的新进展：不再仅仅专注于增强骨骼肌力量。
New advances in clinical application of neostigmine: no longer focusing solely on increasing skeletal muscle strength.
作者信息
Si Shangkun, Zhao Xiaohu, Su Fan, Lu Hongxiu, Zhang Dongbin, Sun Li, Wang Fulei, Xu Li
机构信息
Shandong University of Traditional Chinese Medicine, Jinan, China.
Department of Anesthesiology, Affiliated Hospital of Shandong University of Traditional Chinese Medicine, Jinan, China.
出版信息
Front Pharmacol. 2023 Aug 4;14:1227496. doi: 10.3389/fphar.2023.1227496. eCollection 2023.
Neostigmine is a clinical cholinesterase inhibitor, that is, commonly used to enhance the function of the cholinergic neuromuscular junction. Recent studies have shown that neostigmine regulates the immune-inflammatory response through the cholinergic anti-inflammatory pathway, affecting perioperative neurocognitive function. This article reviews the relevant research evidence over the past 20 years, intending to provide new perspectives and strategies for the clinical application of neostigmine.
新斯的明是一种临床胆碱酯酶抑制剂，也就是说，常用于增强胆碱能神经肌肉接头的功能。最近的研究表明，新斯的明通过胆碱能抗炎途径调节免疫炎症反应，影响围手术期神经认知功能。本文回顾了过去20年的相关研究证据，旨在为新斯的明的临床应用提供新的视角和策略。
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