Batista M C, Bravo N, Cartledge T P, Loriaux D L, Merriam G R, Nieman L K
Developmental Endocrinology Branch, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, Maryland.
Obstet Gynecol. 1993 Mar;81(3):439-43.
To determine whether serum levels of placental protein 14, a major product of the progesterone-induced secretory endometrium, accurately reflect histologic maturation of the endometrium.
Daily serum levels of placental protein 14 were compared in 50 normally cycling women with normal or delayed endometrial maturation, as assessed by histologic dating of an endometrial biopsy in the midluteal phase of the same cycle. Ten of these subjects had placental protein 14 measurements but no biopsy in an additional cycle to examine the potential effects of the biopsy on secretion of this protein.
Serum placental protein 14 concentrations started to increase 8 days after the LH surge and peaked at similar levels on the first day of the next menses in biopsy and non-biopsy cycles. The biopsy cycles had a shorter luteal phase but a slightly faster increase in placental protein 14 concentrations. Both the integrated secretion of this protein and single measurements on the day of the biopsy or at the onset of the next menses overlapped substantially in women with different degrees of endometrial development, even when differentiation of the endometrium was severely delayed.
Serum measurements of placental protein 14 do not accurately predict, and thus should not replace, histologic evaluation of the endometrium at nidation.
确定胎盘蛋白14（孕激素诱导的分泌期子宫内膜的主要产物）的血清水平是否能准确反映子宫内膜的组织学成熟度。
对50名月经周期正常的女性进行研究，根据同一周期黄体中期子宫内膜活检的组织学分期评估其子宫内膜成熟正常或延迟情况，比较每日血清胎盘蛋白14水平。其中10名受试者在另一个周期进行了胎盘蛋白14测量但未做活检，以检查活检对该蛋白分泌的潜在影响。
在促黄体生成素高峰后8天，血清胎盘蛋白14浓度开始升高，并在活检周期和未活检周期的下次月经第一天达到相似的峰值水平。活检周期的黄体期较短，但胎盘蛋白14浓度升高略快。即使子宫内膜分化严重延迟，不同程度子宫内膜发育的女性，该蛋白的综合分泌量以及在活检当天或下次月经开始时的单次测量值也有很大重叠。
血清胎盘蛋白14测量不能准确预测着床时子宫内膜的组织学情况，因此不应用于替代组织学评估。
