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三叉神经痛灰质改变的多模态荟萃分析。

A multimodal meta-analysis of gray matter alterations in trigeminal neuralgia.

作者信息

Huang Xiang, Li Boyi, Li Yuming, Lin Junyu, Shang Huifang, Yang Jing

机构信息

Department of Neurology, West China Hospital of Sichuan University, Chengdu, Sichuan, China.

Department of Radiology, West China Hospital of Sichuan University, Chengdu, Sichuan, China.

出版信息

Front Neurol. 2023 Aug 3;14:1179896. doi: 10.3389/fneur.2023.1179896. eCollection 2023.

DOI:10.3389/fneur.2023.1179896
PMID:37602249
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10436096/
Abstract

BACKGROUND

Brain gray matter alterations in patients with trigeminal neuralgia (TN) have been detected in prior neuroimaging studies, but the results are heterogeneous. The current study conducted coordinate-based meta-analyses across neuroimaging studies, aiming to find the pattern of brain anatomic and functional alterations in patients with TN.

METHODS

We performed a systematic literature search of PubMed, Embase, and Web of Science to identify relevant publications. A multimodal meta-analysis for whole-brain voxel-based morphometry (VBM) studies and functional imaging studies in TN was performed using anisotropic effect size-based signed differential mapping.

RESULTS

The meta-analysis comprised 10 VBM studies with 398 TN patients and 275 healthy controls, and 13 functional magnetic resonance imaging studies with 307 TN patients and 264 healthy controls. The multimodal meta-analysis showed conjoint structural and functional brain alterations in the right fusiform gyrus and inferior temporal gyrus, bilateral thalamus, left superior temporal gyrus, left insula, and inferior frontal gyrus. The unimodal meta-analysis showed decreased gray matter volume alone in the left putamen, left postcentral gyrus, and right amygdala as well as only functional abnormalities in the left cerebellum, bilateral precuneus, and left middle temporal gyrus.

CONCLUSION

This meta-analysis revealed overlapping anatomic and functional gray matter abnormalities in patients with TN, which may help provide new insights into the neuropathology and potential treatment biomarkers of TN.

摘要

背景

先前的神经影像学研究已检测到三叉神经痛（TN）患者的脑灰质改变，但结果存在异质性。本研究对神经影像学研究进行基于坐标的荟萃分析，旨在找出TN患者脑解剖和功能改变的模式。

方法

我们对PubMed、Embase和Web of Science进行了系统的文献检索，以确定相关出版物。使用基于各向异性效应大小的符号差异映射对TN的全脑基于体素的形态计量学（VBM）研究和功能成像研究进行多模态荟萃分析。

结果

荟萃分析包括10项VBM研究（398例TN患者和275例健康对照）以及13项功能磁共振成像研究（307例TN患者和264例健康对照）。多模态荟萃分析显示，右侧梭状回和颞下回、双侧丘脑、左侧颞上回、左侧岛叶和额下回存在联合的结构和功能脑改变。单模态荟萃分析显示，左侧壳核、左侧中央后回和右侧杏仁核灰质体积单独减少，以及左侧小脑、双侧楔前叶和左侧颞中回仅存在功能异常。

结论

这项荟萃分析揭示了TN患者存在重叠的解剖和功能灰质异常，这可能有助于为TN的神经病理学和潜在治疗生物标志物提供新的见解。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e359/10436096/0a6942d8756a/fneur-14-1179896-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e359/10436096/8f24a88a973a/fneur-14-1179896-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e359/10436096/786c19673e1e/fneur-14-1179896-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e359/10436096/40b44e7d1e52/fneur-14-1179896-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e359/10436096/30ad93fc7804/fneur-14-1179896-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e359/10436096/00d8bfeb8c9f/fneur-14-1179896-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e359/10436096/0a6942d8756a/fneur-14-1179896-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e359/10436096/8f24a88a973a/fneur-14-1179896-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e359/10436096/786c19673e1e/fneur-14-1179896-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e359/10436096/40b44e7d1e52/fneur-14-1179896-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e359/10436096/30ad93fc7804/fneur-14-1179896-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e359/10436096/00d8bfeb8c9f/fneur-14-1179896-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e359/10436096/0a6942d8756a/fneur-14-1179896-g006.jpg

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