来自光滑蔷薇根中的新三萜糖苷

New triterpene glucosides from the roots of Rosa laevigata Michx.

作者信息

Yuan Jing-Quan, Yang Xin-Zhou, Miao Jian-Hua, Tang Chun-Ping, Ke Chang-Qiang, Zhang Ji-Bao, Ma Xiao-Jun, Ye Yang

机构信息

Guangxi Institute of Medicinal Plant, Nanning 530023, P.R. China.

出版信息

Molecules. 2008 Sep 22;13(9):2229-37. doi: 10.3390/molecules13092229.

DOI:10.3390/molecules13092229

PMID:18830152

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC6244960/

Abstract

Two new ursane-type triterpene glucosides, 2alpha,3alpha,24-trihydroxyurs-12,18-dien-28-oic acid beta-D-glucopyranosyl ester (1) and 2alpha,3alpha,23-trihydroxyurs-12,19(29)-dien-28-oic acid beta-D-glucopyranosyl ester (2), were isolated from the roots of Rosa laevigata, together with three known compounds: 2alpha,3beta,19alpha-trihydroxyurs-12-en-28-oic acid beta-Dglucopyranosyl ester (3), 2alpha,3alpha,19alpha-trihydroxyurs-12-en-28-oic acid beta-D-glucopyranosyl ester (4) and 2alpha,3beta,19alpha,23-tetrahydroxyurs-12-en-28-oic acid beta-D-glucopyranosyl ester (5). The structures of new compounds were established on the basis of detailed 1D and 2D NMR spectroscopic analyses. Compounds 2 and 5 exhibited modest in vitro antifungal activities against Candida albicans and C. krusei.

摘要

从金樱子根部分离得到两个新的乌苏烷型三萜糖苷，2α,3α,24-三羟基乌苏-12,18-二烯-28-酸β-D-吡喃葡萄糖酯（1）和2α,3α,23-三羟基乌苏-12,19(29)-二烯-28-酸β-D-吡喃葡萄糖酯（2），以及三个已知化合物：2α,3β,19α-三羟基乌苏-12-烯-28-酸β-D-吡喃葡萄糖酯（3）、2α,3α,19α-三羟基乌苏-12-烯-28-酸β-D-吡喃葡萄糖酯（4）和2α,3β,19α,23-四羟基乌苏-12-烯-28-酸β-D-吡喃葡萄糖酯（5）。通过详细的一维和二维核磁共振光谱分析确定了新化合物的结构。化合物2和5对白色念珠菌和克柔念珠菌表现出适度的体外抗真菌活性。