Tessier P, Cartier A, L'Archevêque J, Ghezzo H, Martin R R, Malo J L
J Allergy Clin Immunol. 1986 Sep;78(3 Pt 1):379-87. doi: 10.1016/0091-6749(86)90021-7.
Eight adult subjects with asthma had isocapnic cold air challenges on 4 different days. Three consecutive tests were performed on each visit with functional recovery between tests. Subjects were asked to breathe dry cold air (-20 degrees C) for progressively increasing levels of minute ventilation (7.5, 15, 30, and 60 L/min and maximal voluntary ventilation) until a 20% fall in FEV1 had been reached or when maximal voluntary ventilation was done. FEV1 was assessed between each level. The doses of respiratory heat exchange and minute ventilation causing 10%, 15%, and 20% changes in FEV1 were interpolated from dose-response curves. The within- and between-day 95% confidence intervals based on a single determination on the loge scale varied from +/- 0.32 to 0.59 for the indices derived from respiratory heat exchange. Reproducibility of the between-day results was more satisfactory than for the corresponding within-day assessments. No significant within-day tachyphylaxis was demonstrated for these indices.
八名成年哮喘患者在4个不同日期接受了等碳酸血症冷空气激发试验。每次就诊时进行连续三次测试，测试之间有功能恢复。受试者被要求呼吸干冷空气（-20摄氏度），分钟通气量逐渐增加（7.5、15、30和60升/分钟以及最大自主通气量），直到第一秒用力呼气容积（FEV1）下降20%或完成最大自主通气量。在每个通气量水平之间评估FEV1。根据剂量-反应曲线内插出导致FEV1变化10%、15%和20%的呼吸热交换剂量和分钟通气量。基于对数尺度单次测定的日内和日间95%置信区间，呼吸热交换得出的指标在±0.32至0.59之间变化。日间结果的可重复性比相应的日内评估更令人满意。这些指标未显示出明显的日内快速耐受现象。
