Pounder R E, Hunt R H, Stekelman M, Milton-Thompson G J, Misiewicz J J
Lancet. 1976 Feb 14;1(7955):337-8. doi: 10.1016/s0140-6736(76)90088-x.
10 patients with benign gastric ulcer were treated with cimetidine 0-8 to 1-6 g/day for six weeks. Relief of symptoms was rapid. Endoscopy at the end of treatment showed that all the ulcers had healed. Healing was not associated with an improvement of acute atrophic gastritis nor with any change of gastric mucosal potential difference. No untoward clinical or laboratory effects were observed.
10例良性胃溃疡患者接受西咪替丁治疗，剂量为每日0.8至1.6克，疗程六周。症状迅速缓解。治疗结束时的内镜检查显示所有溃疡均已愈合。溃疡愈合与急性萎缩性胃炎的改善无关，也与胃黏膜电位差的任何变化无关。未观察到不良的临床或实验室效应。
