Zelenty William D, Li Tim Y, Okano Ichiro, Hughes Alexander P, Sama Andrew A, Soffin Ellen M
Department of Orthopaedic Surgery, Spine Service, Hospital for Special Surgery, New York, NY, 10021, USA.
Weill-Cornell Medical College, New York, NY, 10021, USA.
J Pain Res. 2023 Aug 16;16:2835-2845. doi: 10.2147/JPR.S419682. eCollection 2023.
The primary objective of this study is to determine if ultrasound-guided erector spinae plane blocks (ESPB) prior to thoracolumbar spinal fusion reduces opioid consumption in the first 24 hours postoperatively. Secondary objectives include ESPB effects on administration of opioids, utilization of intravenous patient-controlled analgesia (IV-PCA), pain scores, length of stay, and opioid related side effects.
A retrospective cohort analysis was performed on consecutive, adult patients undergoing primary thoracolumbar fusion procedures. Demographic and baseline characteristics including diagnoses of chronic pain, anxiety, depression, and preoperative use of opioids were collected. Surgical data included surgical levels, opioid administration, and duration. Postoperative data included pain scores, opioid consumption, IV-PCA duration, opioid-related side effects, ESPB-related complications, and length of stay (LOS). Statistical analysis was performed using chi-squared and -test analyses, multivariable analysis, and covariate adjustment with propensity score.
A total of 118 consecutive primary thoracolumbar fusions were identified between October 2019 and December 2021 (70 ESPB, 48 no-block [NB]). There were no significant demographic or surgical differences between groups. Median surgical time (262.50 mins vs 332.50 mins, p = 0.04), median intraoperative opioid consumption (8.11 OME vs 1.73 OME, p = 0.01), and median LOS (152.00 hrs vs 128.50 hrs, p = 0.01) were significantly reduced in the ESPB group. Using multivariable covariate adjustment with propensity score analysis only intraoperative opioid administration was found to be significantly less in the ESPB cohort.
ESPB for thoracolumbar fusion can be performed safely in index cases. There was a reduction of intraoperative opioid administration in the ESPB group, however the care team was not blinded to the intervention. Extensive thoracolumbar spinal fusion surgery may require a different approach to regional anesthesia to be similarly effective as ESPB in isolated lumbar surgeries.
本研究的主要目的是确定在胸腰椎脊柱融合术前进行超声引导下竖脊肌平面阻滞(ESPB)是否能减少术后24小时内的阿片类药物消耗量。次要目标包括ESPB对阿片类药物给药、静脉自控镇痛(IV-PCA)的使用、疼痛评分、住院时间以及阿片类药物相关副作用的影响。
对连续接受初次胸腰椎融合手术的成年患者进行回顾性队列分析。收集人口统计学和基线特征,包括慢性疼痛、焦虑、抑郁的诊断以及术前阿片类药物的使用情况。手术数据包括手术节段、阿片类药物给药情况和手术时长。术后数据包括疼痛评分、阿片类药物消耗量、IV-PCA持续时间、阿片类药物相关副作用、ESPB相关并发症以及住院时间(LOS)。使用卡方检验和t检验分析、多变量分析以及倾向评分的协变量调整进行统计分析。
在2019年10月至2021年12月期间共确定了118例连续的初次胸腰椎融合手术患者(70例接受ESPB,48例未阻滞[NB])。两组之间在人口统计学或手术方面无显著差异。ESPB组的中位手术时间(262.50分钟对332.50分钟,p = 0.04)、中位术中阿片类药物消耗量(8.11 OME对1.73 OME,p = 0.01)和中位住院时间(152.00小时对128.50小时,p = 0.01)均显著缩短。使用倾向评分分析进行多变量协变量调整后,发现ESPB队列中仅术中阿片类药物给药量显著减少。
胸腰椎融合术的ESPB在初次手术病例中可安全进行。ESPB组术中阿片类药物给药量减少,但护理团队未对干预措施设盲。广泛的胸腰椎脊柱融合手术可能需要采用不同的区域麻醉方法才能与ESPB在单纯腰椎手术中同样有效。