Andrews Michael, Gao Hanzhi, Datta Santanu, Katz Joseph
Department of Health Services Research, Management and Policy, College of Public Health and Health Professions, University of Florida, Gainesville, FL, USA.
Department of Biostatistics, College of Public Health and Health Professions, University of Florida, Gainesville, FL, USA.
Clin Oral Investig. 2023 Oct;27(10):5925-5933. doi: 10.1007/s00784-023-05204-x. Epub 2023 Aug 22.
Periodontal disease has been linked to multiple systemic conditions, but the relationship with COVID-19 still needs to be elucidated. We hypothesized that periodontal disease may be associated with COVID-19 infection.
This study utilized cross-sectional data to establish the strength of the association between periodontal disease and COVID-19 infection. The University of Florida Health Center's i2b2 patient's registry was used to generate patient counts through ICD-10 diagnostic codes. Univariate descriptive statistics of the patient population and logistic regression to estimate odds ratios of associations between periodontal disease and COVID-19 infection were used for analysis.
Patients with periodontal disease were 4.4 times more likely to be positively diagnosed with COVID-19 than patients without PD. Associations remained similar and robust (P value < 0.0001) after adjustment for age (OR = 4.34; 95% CI, 3.68-5.09), gender (OR = 4.46; 95% CI, 3.79-5.23), and smoking status (OR = 4.77; 95% CI, 4.04-5.59). Associations were smaller but remained robust (P value < 0.0001) after adjusting for race (OR = 2.83; 95% CI, 2.40-3.32), obesity (OR = 2.53; 95% CI, 2.14-2.98), diabetes (OR = 3.32; 95% CI, 2.81-3.90), and cardiovascular disease (OR = 2.68; 95% CI, 2.27-3.14).
Periodontal disease is significantly associated with increased odds for COVID-19 infection.
With the caveat of a cross-sectional study design, these results suggest that periodontal disease may increase the odds for COVID-19 infection.
牙周疾病已与多种全身性疾病相关联，但与新型冠状病毒肺炎（COVID-19）的关系仍有待阐明。我们推测牙周疾病可能与COVID-19感染有关。
本研究利用横断面数据来确定牙周疾病与COVID-19感染之间关联的强度。佛罗里达大学健康中心的i2b2患者登记系统通过国际疾病分类第十版（ICD-10）诊断编码来生成患者计数。对患者群体进行单变量描述性统计，并采用逻辑回归来估计牙周疾病与COVID-19感染之间关联的比值比，以进行分析。
患有牙周疾病的患者被确诊感染COVID-19的可能性是未患牙周疾病患者的4.4倍。在对年龄（比值比[OR]=4.34；95%置信区间[CI]，3.68 - 5.09）、性别（OR = 4.46；95% CI，3.79 - 5.23）和吸烟状况（OR = 4.77；95% CI，4.04 - 5.59）进行调整后，关联仍然相似且显著（P值<0.0001）。在对种族（OR = 2.83；95% CI，2.40 - 3.32）、肥胖（OR = 2.53；95% CI，2.14 - 2.98）、糖尿病（OR = 3.32；95% CI，2.81 - 3.90）和心血管疾病（OR = 2.68；95% CI，2.27 - 3.14）进行调整后，关联虽变小但仍然显著（P值<0.0001）。
牙周疾病与COVID-19感染几率增加显著相关。
鉴于本研究为横断面研究设计，这些结果表明牙周疾病可能会增加COVID-19感染的几率。
