Melzack R, Mount B M, Gordon J M
Can Med Assoc J. 1979 Feb 17;120(4):435-8.
The Brompton mixture is widely used as an effective method for controlling pain in cancer patients. In a double-blind crossover trial a standard Brompton mixture containing morphine, cocaine, ethyl alcohol, syrup BP and chloroform water was compared with morphine alone in a flavoured aqueous solution; both were administered orally. Pain was measured by means of the pain intensity index of the McGill Pain Questionnaire. Ratings of confusion, nausea and drowsiness were obtained from both the patients and their nurses and relatives. The data showed that there was no significant difference between the Brompton mixture and morphine administered orally for any of the variables. Both relieved pain effectively in about 85% of the patients.
布朗普顿合剂被广泛用作控制癌症患者疼痛的有效方法。在一项双盲交叉试验中，将含有吗啡、可卡因、乙醇、英国药典糖浆和氯仿水的标准布朗普顿合剂与单独的吗啡加调味水溶液进行了比较；两者均口服给药。通过麦吉尔疼痛问卷的疼痛强度指数来测量疼痛。从患者及其护士和亲属那里获得了关于意识模糊、恶心和嗜睡的评分。数据表明，对于任何变量，布朗普顿合剂和口服吗啡之间没有显著差异。两者在约85%的患者中均有效缓解了疼痛。
