优化 SARC-F 在肌肉无力识别中的使用，考虑替代切点：纽卡斯尔 SarcScreen 项目的研究结果。
Optimising the use of SARC-F for the identification of muscle weakness by considering alternative cut-points: findings from the Newcastle SarcScreen project.
机构信息
AGE Research Group, Translational and Clinical Research Institute, Faculty of Medical Sciences, Newcastle University, Biomedical Research Building, Campus for Ageing and Vitality, Newcastle upon Tyne, NE4 5PL, UK.
NIHR Newcastle Biomedical Research Centre, Newcastle upon Tyne NHS Foundation Trust, Cumbria Northumberland Tyne and Wear NHS Foundation Trust and Newcastle University, Newcastle upon Tyne, UK.
出版信息
Eur Geriatr Med. 2023 Dec;14(6):1327-1331. doi: 10.1007/s41999-023-00850-6. Epub 2023 Aug 22.
PURPOSE
We assessed the impact of applying different SARC-F cut-points for the identification of muscle weakness in an older clinical population.
METHODS
We included 159 men and 311 women aged 56-98 years who had completed the SARC-F questionnaire and had their maximum grip strength measured at an Older People's Medicine Day Unit. We applied cut-points of ≥ 4, 3 and 2 to SARC-F and tested agreement with muscle weakness (grip strength < 27kg men, < 16kg women) in analyses stratified by sex and obesity status.
RESULTS
Prevalence of muscle weakness was 86.8% and 82.6% in men and women, respectively. Sensitivity of the SARC-F increased at lower cut-points (e.g. 81% for ≥ 4 vs 97% for ≥ 2 in women). There was typically greater sensitivity among women than men and among those classified as obese vs non-obese.
CONCLUSIONS
These findings suggest that different cut-points may be required to optimise the utility of SARC-F for identifying muscle weakness in different patient sub-groups.
目的
我们评估了在老年临床人群中应用不同 SARC-F 切点识别肌肉无力的影响。
方法
我们纳入了 159 名男性和 311 名年龄在 56-98 岁之间的男性和女性，他们完成了 SARC-F 问卷，并在老年人医学日单位测量了最大握力。我们应用 SARC-F 的切点≥4、3 和 2，并在按性别和肥胖状况分层的分析中检验了与肌肉无力（男性握力<27kg，女性握力<16kg）的一致性。
结果
男性和女性肌肉无力的患病率分别为 86.8%和 82.6%。较低切点的 SARC-F 敏感性增加（例如，女性切点≥4 的敏感性为 81%，而切点≥2 的敏感性为 97%）。女性的敏感性通常高于男性，肥胖组的敏感性高于非肥胖组。
结论
这些发现表明，可能需要不同的切点来优化 SARC-F 在不同患者亚组中识别肌肉无力的效用。
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