Zbar B, Canti G, Rapp H J, Bier J, Borsos T
Cancer. 1979 Apr;43(4):1304-7. doi: 10.1002/1097-0142(197904)43:4<1304::aid-cncr2820430418>3.0.co;2-l.
Oral tumors with associated cervical lymph node metastases developed after injection of tumor cells into buccal pads of inbred guinea pigs. Intralesional injection of living BCG or BCG cell walls (CW) caused regression of established tumors, prevented the development of cervical lymph node metastases and led to the development of host resistance to the growth of subsequent tumor transplant.
将肿瘤细胞注射到近交系豚鼠的颊垫后,出现了伴有颈部淋巴结转移的口腔肿瘤。瘤内注射活卡介苗或卡介苗细胞壁(CW)可使已形成的肿瘤消退,防止颈部淋巴结转移的发生,并导致宿主对随后肿瘤移植生长产生抗性。