Yamashita Koji, Yoneyama Masami, Kikuchi Kazufumi, Wada Tatsuhiro, Murazaki Hiroo, Watanuki Hiroaki, Mikayama Ryoji, Ishigami Kousei, Togao Osamu
Departments of Radiology Informatics and Network, Graduate School of Medical Sciences, Kyushu University, 3-1-1, Maidashi, Higashi-ku, Fukuoka 812-8582, Japan.
Philips Japan, 13-37, Kohnan 2-chome, Minato-ku, Tokyo 108-8507, Japan.
Eur J Radiol Open. 2023 Aug 11;11:100516. doi: 10.1016/j.ejro.2023.100516. eCollection 2023 Dec.
To assess the reproducibility of ADC, T1, T2, and proton density (PD) measurements on the cortex across the entire brain using high-resolution pseudo-3D diffusion-weighted imaging using echo-planar imaging with compressed SENSE (EPICS-DWI) and 3D quantification with an interleaved Look-Locker acquisition sequence with T2 preparation pulse (3D-QALAS) in normal healthy adults.
Twelve healthy participants (median age, 33 years; range, 28-51 years) were recruited to evaluate the reproducibility of whole-brain EPICS-DWI and synthetic MRI. EPICS-DWI utilizes a compressed SENSE reconstruction framework while maintaining the EPI sampling pattern. The 3D-QALAS sequence is based on multi-acquisition 3D gradient echo, with five acquisitions equally spaced in time, interleaved with a T2 preparation pulse and an inversion pulse. EPICS-DWI ( values, 0 and 1000 s/mm) and 3D-QALAS sequence with identical voxel size on a 3.0-T MR system were performed twice (for test-retest scan). Intraclass correlation coefficients (ICCs) for ADC, T1, T2, and PD for all parcellated volume of interest (VOI) per subject on scan-rescan tests were calculated to assess reproducibility. Bland-Altman plots were used to investigate discrepancies in ADCs, T1s, T2s, and PDs obtained from the two MR scans.
The ICC of ADCs was 0.785, indicating "good" reproducibility. The ICCs of T1s, T2s, and PDs were 0.986, 0.978, and 0.968, indicating "excellent" reproducibility.
The combination of EPICS-DWI and 3D-QALAS sequences with identical voxel size could reproducible ADC, T1, T2, and PD measurements for the cortex across the entire brain in healthy adults.
使用具有压缩感知的回波平面成像的高分辨率伪三维扩散加权成像（EPICS-DWI）和带有T2准备脉冲的交错Look-Locker采集序列的三维定量（3D-QALAS），评估正常健康成年人全脑皮质上ADC、T1、T2和质子密度（PD）测量的可重复性。
招募了12名健康参与者（年龄中位数为33岁；范围为28 - 51岁）来评估全脑EPICS-DWI和合成MRI的可重复性。EPICS-DWI利用压缩感知重建框架，同时保持EPI采样模式。3D-QALAS序列基于多次采集的三维梯度回波，在时间上均匀间隔进行五次采集，并与T2准备脉冲和反转脉冲交错。在3.0-T MR系统上，使用相同体素大小的EPICS-DWI（值为0和1000 s/mm²）和3D-QALAS序列进行两次扫描（用于重测扫描）。计算扫描-重测测试中每个受试者所有分割感兴趣体积（VOI）的ADC、T1、T2和PD的组内相关系数（ICC），以评估可重复性。使用Bland-Altman图来研究两次MR扫描获得的ADC、T1、T2和PD的差异。
ADC的ICC为0.785，表明具有“良好”的可重复性。T1、T2和PD的ICC分别为0.986、0.978和0.968，表明具有“优秀”的可重复性。
相同体素大小的EPICS-DWI和3D-QALAS序列的组合能够在健康成年人中对全脑皮质进行可重复的ADC、T1、T2和PD测量。
