Department of Environmental Medicine and Public Health, Icahn School of Medicine at Mount Sinai, New York, New York, USA.
Icahn School of Medicine at Mount Sinai, New York, New York, USA.
Child Dev. 2024 Jan-Feb;95(1):e47-e59. doi: 10.1111/cdev.13997. Epub 2023 Aug 23.
In-utero exposures interact in complex ways that influence neurodevelopment. Animal research demonstrates that fetal sex moderates the impact of joint exposure to metals and prenatal stress measures, including cortisol, on offspring socioemotional outcomes. Further research is needed in humans. We evaluated the joint association of prenatal exposures to a metal mixture and cortisol with infant negative affectivity, considering sex differences. Analyses included 226 (29% White, Non-Hispanic) mother-infant pairs with data on exposures and negative affectivity assessed using the Infant Behavior Questionnaire-Revised in 6-month-olds. Results showed that girls whose mothers had higher cortisol had significantly higher scores of Fear and Sadness with greater exposure to the mixture. Examining higher-order interactions may better elucidate the effects of prenatal exposure to metals and cortisol on socioemotional functioning.
宫内暴露以复杂的方式相互作用，影响神经发育。动物研究表明，胎儿性别调节了金属和产前应激措施（包括皮质醇）联合暴露对后代社会情感结果的影响。需要在人类中进一步研究。我们评估了产前暴露于金属混合物和皮质醇与婴儿负性情绪之间的联合关联，同时考虑了性别差异。分析包括 226 对（29%为白人，非西班牙裔）母婴对，使用修订后的婴儿行为问卷评估了暴露和负性情绪的数据。结果表明，母亲皮质醇水平较高的女孩，在接触混合物时，恐惧和悲伤的得分明显更高。检查更高阶的相互作用可能会更好地阐明产前暴露于金属和皮质醇对社会情感功能的影响。
