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mRNA 疫苗在癌症治疗中的应用：现状与展望。

mRNA vaccine in cancer therapy: Current advance and future outlook.

机构信息

Department of Breast Surgery, Baoji Municipal Central Hospital, Weibin District, Baoji, Shaanxi, China.

Graduate School, Beijing University of Chinese Medicine, Beijing, China.

出版信息

Clin Transl Med. 2023 Aug;13(8):e1384. doi: 10.1002/ctm2.1384.

DOI:10.1002/ctm2.1384
PMID:37612832
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10447885/
Abstract

Messenger ribonucleic acid (mRNA) vaccines are a relatively new class of vaccines that have shown great promise in the immunotherapy of a wide variety of infectious diseases and cancer. In the past 2 years, SARS-CoV-2 mRNA vaccines have contributed tremendously against SARS-CoV2, which has prompted the arrival of the mRNA vaccine research boom, especially in the research of cancer vaccines. Compared with conventional cancer vaccines, mRNA vaccines have significant advantages, including efficient production of protective immune responses, relatively low side effects and lower cost of acquisition. In this review, we elaborated on the development of cancer vaccines and mRNA cancer vaccines, as well as the potential biological mechanisms of mRNA cancer vaccines and the latest progress in various tumour treatments, and discussed the challenges and future directions for the field.

摘要

信使核糖核酸（mRNA）疫苗是一类相对较新的疫苗，在多种传染病和癌症的免疫治疗中显示出巨大的潜力。在过去的 2 年中，SARS-CoV-2 mRNA 疫苗在对抗 SARS-CoV2 方面发挥了巨大作用，这促使 mRNA 疫苗研究热潮的到来，特别是在癌症疫苗的研究中。与传统的癌症疫苗相比，mRNA 疫苗具有显著的优势，包括高效产生保护性免疫反应、相对较低的副作用和较低的获取成本。在这篇综述中，我们详细阐述了癌症疫苗和 mRNA 癌症疫苗的发展，以及 mRNA 癌症疫苗的潜在生物学机制和各种肿瘤治疗的最新进展，并讨论了该领域的挑战和未来方向。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4664/10447885/aa5d9b408230/CTM2-13-e1384-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4664/10447885/dcb2d6203e7e/CTM2-13-e1384-g008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4664/10447885/978e586eb787/CTM2-13-e1384-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4664/10447885/c808562b9469/CTM2-13-e1384-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4664/10447885/9bb42ada4ced/CTM2-13-e1384-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4664/10447885/cc0382a647e3/CTM2-13-e1384-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4664/10447885/b06d70e57ad7/CTM2-13-e1384-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4664/10447885/aa5d9b408230/CTM2-13-e1384-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4664/10447885/dcb2d6203e7e/CTM2-13-e1384-g008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4664/10447885/978e586eb787/CTM2-13-e1384-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4664/10447885/c808562b9469/CTM2-13-e1384-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4664/10447885/9bb42ada4ced/CTM2-13-e1384-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4664/10447885/cc0382a647e3/CTM2-13-e1384-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4664/10447885/b06d70e57ad7/CTM2-13-e1384-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4664/10447885/aa5d9b408230/CTM2-13-e1384-g007.jpg

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